尿酸对帕金森病保护作用的研究进展
发布时间：2018-08-31 15:46
【摘要】：帕金森病(Parkinson`s disease PD)是中老年人神经系统常见的运动障碍性疾病，，其主要的病理特征是黑质、纹状体系统多巴胺（dopamine，DA）能神经元进行性变性、丢失，中脑黑质神经元内路易小体(Lewy body)形成，临床表现为静止性震颤、肌强直、运动迟缓等运动障碍症状和认知功能下降、抑郁、睡眠障碍、嗅觉功能减退、便秘等非运动症状。PD病因与遗传因素、环境因素、年龄因素密切相关，在环境和遗传因素相互作用的结果下，通过氧化应激、线粒体功能障碍、易聚集蛋白错误折叠、聚集和降解异常、免疫炎症反应、兴奋性神经毒性作用等机制导致黑质多巴胺能神经元大量变性、丢失。尿酸（Uric acid, UA）是体内腺苷、鸟苷和饮食中细胞内核糖核酸嘌呤代谢的终产物，是人体内生理性的抗氧化物质,流行病学及临床研究提示，PD患者的尿酸水平显著降低，低尿酸水平与帕金森病(PD)发病率增高密切相关，高水平的血UA和脑脊液UA可以减慢PD病人的病情进展。尿酸与PD患者的疗效减退、非运动症状的发生亦有一定的关系。基础研究结果证实尿酸对多巴胺能神经元具有保护作用。调节尿酸水平有希望作为帕金森病防治的潜在新靶点。
[Abstract]:Parkinson's disease (Parkinson's disease PD) is a common motor disorder in the nervous system of middle and old people. Its main pathological features are substantia nigra and progressive degeneration and loss of dopaminergic neurons in the striatum system. (Lewy body) of Lewy corpuscles in substantia nigra neurons was formed. The clinical manifestations were static tremor, myotonia, motor retardation, depression, sleep disorder, and decreased olfactory function. The etiology of constipation is closely related to genetic factors, environmental factors and age factors. Under the interaction of environmental and genetic factors, it is easy to fold aggregation protein by oxidative stress, mitochondrial dysfunction, etc. Abnormal aggregation and degradation, immune inflammation, excitatory neurotoxicity and other mechanisms lead to a large number of degeneration and loss of dopaminergic neurons in the substantia nigra. Uric acid (Uric acid, UA) is the end product of adenosine, guanosine and intracellular ribonucleic acid purine metabolism in human body. Low uric acid level was closely associated with the increased incidence of (PD) in Parkinson's disease. High levels of serum UA and cerebrospinal fluid UA could slow down the progression of PD patients. Uric acid is also associated with the decrease of curative effect and the occurrence of non-motor symptoms in patients with PD. The basic results confirm that uric acid has protective effect on dopaminergic neurons. Regulation of uric acid levels may be a potential new target for the prevention and treatment of Parkinson's disease.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.5
本文编号：2215444
[Abstract]:Parkinson's disease (Parkinson's disease PD) is a common motor disorder in the nervous system of middle and old people. Its main pathological features are substantia nigra and progressive degeneration and loss of dopaminergic neurons in the striatum system. (Lewy body) of Lewy corpuscles in substantia nigra neurons was formed. The clinical manifestations were static tremor, myotonia, motor retardation, depression, sleep disorder, and decreased olfactory function. The etiology of constipation is closely related to genetic factors, environmental factors and age factors. Under the interaction of environmental and genetic factors, it is easy to fold aggregation protein by oxidative stress, mitochondrial dysfunction, etc. Abnormal aggregation and degradation, immune inflammation, excitatory neurotoxicity and other mechanisms lead to a large number of degeneration and loss of dopaminergic neurons in the substantia nigra. Uric acid (Uric acid, UA) is the end product of adenosine, guanosine and intracellular ribonucleic acid purine metabolism in human body. Low uric acid level was closely associated with the increased incidence of (PD) in Parkinson's disease. High levels of serum UA and cerebrospinal fluid UA could slow down the progression of PD patients. Uric acid is also associated with the decrease of curative effect and the occurrence of non-motor symptoms in patients with PD. The basic results confirm that uric acid has protective effect on dopaminergic neurons. Regulation of uric acid levels may be a potential new target for the prevention and treatment of Parkinson's disease.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.5
【参考文献】
相关期刊论文 前6条
1 姚庆和,高国栋;肌苷对帕金森病小鼠模型的神经保护作用[J];第四军医大学学报;2005年02期
2 叶艳;罗蔚锋;朱婷鸽;杨亚萍;周旭平;刘春风;包仕尧;;尿酸减轻6-羟基多巴胺对PC12细胞的毒性作用[J];中国临床神经科学;2010年02期
3 陈先文,陈生弟,刘振国,肖勤,王瑛,翁中芳;铁剂诱发黑质多巴胺能神经元变性[J];中华老年医学杂志;2002年01期
4 路巍;王颜刚;阎胜利;宋达琳;;高尿酸血症血尿酸与TNF-α、IL-6的关系[J];中华内分泌代谢杂志;2007年02期
5 王晓君;罗蔚锋;王丽君;刘春风;;女性帕金森病患者血尿酸水平的研究[J];中国神经精神疾病杂志;2009年05期
6 缪桂华;张宁;舒海洋;张琪林;刘晶;罗蔚锋;;不同剂量尿酸保护性治疗帕金森病大鼠对炎性因子、肾、关节及血管内皮的影响[J];医学研究杂志;2014年04期
本文编号：2215444
本文链接：https://www.wllwen.com/yixuelunwen/shenjingyixue/2215444.html
最近更新
教材专著
