中介素与肾上腺髓质素对局灶性脑缺血大鼠脑微循环的影响

发布时间：2018-09-01 11:10

【摘要】：目的探讨中介素(intermedin,IMD)与肾上腺髓质素(adrenomedullin,ADM)对局灶性脑缺血大鼠脑微循环的影响。方法采用大脑中动脉闭塞法构建脑缺血(cerebral ischemia,CI)大鼠模型,将40只SPF级雄性SD大鼠随机分为3组:脑缺血模型+生理盐水[CI+NS(normal saline,NS)]组、CI模型+ADM处理(CI+ADM)组与CI模型+IMD处理(CI+IMD)组,采用激光多普勒测定仪监测脑表面微循环灌注量的变化。结果 CI+NS组、CI+ADM组与CI+IMD组大鼠脑表面微循环灌注量的比较,差异有显著性(P0.05),事后多重比较发现,CI+IMD组大鼠脑表面微循环灌注量均高于CI+NS组与CI+ADM组。结论 IMD可以改善局灶性脑缺血大鼠脑微循环,且疗效优于ADM。
[Abstract]:Objective to investigate the effects of intermedin,IMD and adrenomedullin,ADM on cerebral microcirculation in rats with focal cerebral ischemia. Methods the rat model of cerebral ischemia (cerebral ischemia,CI) was established by middle cerebral artery occlusion. Forty male SD rats of SPF grade were randomly divided into three groups: ADM treated with (CI ADM) and (CI IMD) treated with CI IMD. The changes of cerebral microcirculation perfusion were monitored by laser Doppler instrument. Results there was a significant difference in the amount of cerebral microcirculation perfusion between the CI NS group and the CI IMD group (P0.05). It was found that the cerebral surface microcirculation perfusion volume in the CI IMD group was higher than that in the CI NS group and CI ADM group. Conclusion IMD can improve cerebral microcirculation in rats with focal cerebral ischemia, and the curative effect is better than that of ADM..
【作者单位】：华北理工大学附属医院神经内科;唐山职业技术学院;华北理工大学心理学院;华北理工大学附属医院神经外科;华北理工大学基础医学院河北省慢性疾病重点实验室唐山市慢性病临床基础研究重点实验室;华北理工大学精神卫生研究所;
【基金】：河北省硕士研究生创新自助项目(CXZZSS2017072) 华北理工大学研究生创新项目(2017S04) 河北省中医药管理局2016年度中医药类科研计划课题(2016079)
【分类号】：R743

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