探讨氯吡格雷联合阿司匹林治疗急性轻度脑梗死的有效性和安全性

发布时间：2018-09-03 16:10

【摘要】：目的:探究治疗急性轻度脑梗死时使用氯吡格雷+阿司匹林的临床效果和应用价值。方法:择取我院于2015年7月至2016年4月期间收治的70例急性轻度脑梗死患者参与本次研究,按患者入院时间划分为单项治疗组和联合治疗组,每组各35例患者。单项治疗组患者接受单纯服用阿司匹林药物进行治疗,联合治疗组患者则行氯吡格雷+阿司匹林进行治疗,观察对比两组患者的病情进展、治疗前、后的神经功能缺损评分测量表(NIHSS)以及治疗后的不良反应情况。结果:治疗前两组患者的NIHSS评分无明显差异(P0.05)无统计学意义,但是治疗后的NIHSS低于治疗前,且数据中存在的差异在统计学中有意义(P0.05)。且联合治疗组患者的治疗有效率高于单项治疗组,经统计学计算数据差异有意义(P0.05)。此外,两组患者均未出现严重的不良反应事件。结论:治疗急性轻度脑梗死时使用氯吡格雷+阿司匹林的临床效果优于单纯的阿司匹林治疗效果,可在临床中应用推广。
[Abstract]:Objective: to explore the clinical effect and value of clopidogrel aspirin in the treatment of acute mild cerebral infarction. Methods: 70 patients with acute mild cerebral infarction admitted in our hospital from July 2015 to April 2016 were selected and divided into single treatment group and combined treatment group with 35 patients in each group according to the time of admission. Patients in the single treatment group were treated with aspirin alone, while those in the combined treatment group were treated with clopidogrel aspirin. (NIHSS) and adverse reactions after treatment. Results: there was no significant difference in NIHSS score between the two groups before treatment (P0.05), but the NIHSS after treatment was lower than that before treatment, and the difference in data was significant in statistics (P0.05). The effective rate of the combined treatment group was higher than that of the single treatment group, and the difference was significant (P0.05). In addition, there were no serious adverse events in both groups. Conclusion: clopidogrel aspirin is more effective than aspirin alone in the treatment of acute mild cerebral infarction.
【作者单位】：南通市第二人民医院神经内科;
【分类号】：R743.33

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