促炎因子TNF-α,IL-1β,IL-6在神经病理性疼痛中的研究进展

发布时间：2018-09-11 09:52

【摘要】：细胞因子可分为促炎性细胞因子和抗炎性细胞因子2种类型。其中,促炎因子是一类由机体的免疫和非免疫细胞合成和分泌的小分子多肽类物质,它们调节多种细胞生理功能,并在创伤、疼痛、感染等应激过程中起重要作用。促炎性细胞因子包括白细胞介素-1(IL-1)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)、肿瘤坏死因子(TNF)等。越来越多证据表明,神经损伤后,促炎因子TNF-α,IL-1β,IL-6在脊髓和背根神经节中被诱导,并且可以导致神经痛敏反应。近年来,随着神经病理性疼痛机制研究的日趋深入和神经炎症研究领域的不断扩展,细胞因子及调控细胞因子的分子在神经病理性疼痛作用机制的阐明,有望为镇痛药物的开发提供新的作用靶点。该文就近年来研究较多的促炎因子TNF-α,IL-1β,IL-6在神经病理性疼痛的研究进行综述。
[Abstract]:Cytokines can be divided into two types: proinflammatory cytokines and anti-inflammatory cytokines. Among them, pro-inflammatory factors are a class of small molecular polypeptides synthesized and secreted by immune and non-immune cells of the body. They regulate many cellular physiological functions and play an important role in stress processes such as trauma, pain, infection and so on. Proinflammatory cytokines include interleukin-1 (IL-1), interleukin-6 (IL-6) and interleukin-8 (IL-8), tumor necrosis factor (TNF) and so on. More and more evidences show that the inflammatory factor TNF- 伪, IL-1 尾 and IL-6 are induced in spinal cord and dorsal root ganglion after nerve injury, and can lead to neuralgia sensitivity. In recent years, with the deepening of the study of neuropathic pain mechanism and the continuous expansion of the field of neuroinflammation, cytokines and cytokines regulating the molecular mechanism of neuropathic pain have been elucidated. It is expected to provide a new target for the development of analgesic drugs. This article reviews the recent studies on the role of TNF- 伪, IL-1 尾 and IL-6 in neuropathic pain.
【作者单位】：中国中医科学院中药研究所;
【基金】：国家自然科学基金面上项目(81473414);国家自然科学基金青年基金项目(81703845) 国家科技支撑计划课题(2011BAI07B00)
【分类号】：R741

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