尤瑞克林对急性脑梗死患者血清ox-LDL、IL-1、VEGF水平的影响
发布时间：2018-09-18 06:32
【摘要】：目的:探讨尤瑞克林对脑梗死患者血清氧化低密度脂蛋白(ox-LDL)、白细胞介素1(IL-1)、血管内皮生长因子(VEGF)水平的影响,探讨尤瑞克林在急性脑梗死生理病理过程中的能够起到抑制氧化反应、抗炎及促血管再生等多个作用。方法:选取66例发病时间在1周内的脑梗死患者,分为实验组(33例)及对照组(33例)。其中实验组男17例,女16例,平均年龄(65.6±1.2)岁;对照组男18例,女15例,平均年龄(65.2±1.7)岁。两组患者年龄、治疗时间等差异无统计学意义。实验组给予尤瑞克林(凯力康,广东天普生化医药股份有限公司)0.15PNA加入0.9%生理盐水100ml,1次/日,静点,同时加用活血化瘀中药、调整血压、调理血糖、调整血脂等治疗,治疗过程平均14天。对照组给予苦碟子(碟脉灵,通化华夏药业有限责任公司)40ml加入0.9%生理盐水250ml中,1次/日,静点,同时加用改善循环药物、调整血压、调理血糖、调整血脂等治疗,治疗过程平均14天。两组患者分别于入院后24小时内采取空腹肘正中静脉血2m L,治疗结束后再次留取静脉血,经离心(4000r/min,3min)后留取血清标本,置于-80℃冰箱保存。实验标本均采用双抗体夹心酶联免疫吸附法(ELISA)测定,试剂盒为深圳晶美公司生产。结果:实验组治疗前血清ox-LDL、IL-1、VEGF水平分别为(136.5±44.3)μg/L、(109.6±34.8)ng/L、(970.8±243.7)ng/L,对照组治疗前血清ox-LDL、IL-1、VEGF水平分别为(137.7±41.8)μg/L、(107.3±29.4)ng/L、(980.0±290.7)ng/L。实验组治疗后血清ox-LDL、IL-1、VEGF水平分别为(112.1±33.3)μg/L、(90.5±29.3)ng/L、(1150.0±240.6)ng/L,对照组治疗后血清ox-LDL、IL-1、VEGF水平分别为(130.0±37.9)μg/L、(105.5±30.5)ng/L、(1012.7±303.3)ng/L。对实验数据进行统计结果显示:治疗前两组患者上述测定指标水平相近,并无统计学差异,治疗后较治疗前均有所改变并具有统计学意义(p),而实验组治疗后的结果变化较对照组更显著(p0.05)。分析得出尤瑞克林能够更好的降低脑梗死患者血清IL-1、ox-LDL水平,并有效提高脑梗死患者血清VEGF水平。结论:1.尤瑞克林能够有效降低急性脑梗死患者血清ox-LDL、IL的水平,从而证实其具有抗氧化、抗炎的药理作用。2.尤瑞克林能够有效提高急性脑梗死患者血清VEGF的水平,在从而证实其具有促血管再生的作用。3.尤瑞克林能够在急性脑梗死多个环节起作用,作为多靶点治疗的新药值得在临床上广泛推广。
[Abstract]:Objective: to investigate the effects of eurexine on the levels of serum oxidized low density lipoprotein (ox-LDL), interleukin 1 (IL-1) and vascular endothelial growth factor (VEGF) in patients with cerebral infarction. To investigate the effects of eucrine in the physiological and pathological process of acute cerebral infarction (ACI), such as inhibiting oxidation, anti-inflammation and promoting vascular regeneration. Methods: 66 patients with cerebral infarction within 1 week were divided into experimental group (33 cases) and control group (33 cases). There were 17 males and 16 females in the experimental group with an average age of (65.6 卤1.2) years, while in the control group, there were 18 males and 15 females with an average age of (65.2 卤1.7) years. There was no significant difference in age and treatment time between the two groups. The experimental group was given 0.15PNA with 0.9% normal saline 100ml / day, plus Chinese herbal medicine for promoting blood circulation and removing blood stasis, adjusting blood pressure, regulating blood sugar, adjusting blood lipid, etc., in the experimental group, the treatment group was treated with 0.15PNA of 0.9% physiological saline once a day, and treated with traditional Chinese medicine for promoting blood circulation and removing blood stasis, adjusting blood pressure, regulating blood sugar, adjusting blood lipid, and so on. The average course of treatment was 14 days. The control group was treated with Kudaizi (Diemailing, Tonghua Huaxia Pharmaceutical Co., Ltd.) 40ml added 0.9% normal saline 250ml once a day, and treated with improving circulation medicine, adjusting blood pressure, regulating blood sugar, regulating blood lipid and so on. The average course of treatment was 14 days. The patients in the two groups were given fasting median elbow venous blood (2m L) within 24 hours after admission. After the treatment, the venous blood was collected again. The serum samples were collected after centrifugation (4 000 r / min ~ 3 min) and stored in a refrigerator at -80 鈩，
本文编号：2247071
[Abstract]:Objective: to investigate the effects of eurexine on the levels of serum oxidized low density lipoprotein (ox-LDL), interleukin 1 (IL-1) and vascular endothelial growth factor (VEGF) in patients with cerebral infarction. To investigate the effects of eucrine in the physiological and pathological process of acute cerebral infarction (ACI), such as inhibiting oxidation, anti-inflammation and promoting vascular regeneration. Methods: 66 patients with cerebral infarction within 1 week were divided into experimental group (33 cases) and control group (33 cases). There were 17 males and 16 females in the experimental group with an average age of (65.6 卤1.2) years, while in the control group, there were 18 males and 15 females with an average age of (65.2 卤1.7) years. There was no significant difference in age and treatment time between the two groups. The experimental group was given 0.15PNA with 0.9% normal saline 100ml / day, plus Chinese herbal medicine for promoting blood circulation and removing blood stasis, adjusting blood pressure, regulating blood sugar, adjusting blood lipid, etc., in the experimental group, the treatment group was treated with 0.15PNA of 0.9% physiological saline once a day, and treated with traditional Chinese medicine for promoting blood circulation and removing blood stasis, adjusting blood pressure, regulating blood sugar, adjusting blood lipid, and so on. The average course of treatment was 14 days. The control group was treated with Kudaizi (Diemailing, Tonghua Huaxia Pharmaceutical Co., Ltd.) 40ml added 0.9% normal saline 250ml once a day, and treated with improving circulation medicine, adjusting blood pressure, regulating blood sugar, regulating blood lipid and so on. The average course of treatment was 14 days. The patients in the two groups were given fasting median elbow venous blood (2m L) within 24 hours after admission. After the treatment, the venous blood was collected again. The serum samples were collected after centrifugation (4 000 r / min ~ 3 min) and stored in a refrigerator at -80 鈩，
本文编号：2247071
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