帕金森病合并抑郁与血清细胞因子的相关研究

发布时间：2018-09-18 16:56

【摘要】：目的检测帕金森病合并抑郁(DPD)、帕金森病(PD)及抑郁症(DD)的血清免疫细胞因子的变化,探讨DPD的细胞因子其变化的相关因素。方法应用酶联免疫吸附法检测77例患者(22例DPD,33例PD,22例DD)及23例健康志愿者其血清IL-6、IL-18和TNF-α水平,并对DPD患者进行相关量表评估。结果 DPD、PD及DD患者外周血清中IL-6和TNF-α均较正常人显著降低,IL-18未见变化;DPD患者经抗抑郁治疗后,其IL-6及TNF-α水平显著升高,但IL-18未见变化;细胞因子水平在DPD患者性别和抑郁严重程度不同中无差异;同时细胞因子水平的变化与DPD的UPDRS-Ⅲ、HY分期、MMSE以及HAMD-24评分不相关。结论外周血清中TNF-α和IL-6水平降低可能是DPD的早期预测指标之一,但外周血清IL-18的作用暂不能肯定。
[Abstract]:Objective to detect the changes of serum immune cytokines in Parkinson's disease (PD) complicated with depression (DPD), Parkinson's disease (PD) and depression (DD), and to explore the related factors of DPD cytokines. Methods Enzyme-linked immunosorbent assay (Elisa) was used to detect the serum IL-6,IL-18 and TNF- 伪 levels in 77 patients (22 patients with DPD,33 PD,22 DD) and 23 healthy volunteers. Results Serum IL-6 and TNF- 伪 levels in patients with DPD,PD and DD were significantly lower than those in normal controls. After antidepressant treatment, the levels of IL-6 and TNF- 伪 in serum of patients with DPD,PD and DD were significantly increased, but no changes were found in IL-18. The level of cytokines had no significant difference in DPD patients with different sex and severity of depression, and there was no correlation between the level of cytokines and the UPDRS- 鈪，

本文编号：2248543