多系统萎缩非运动症候的临床研究

发布时间：2018-09-19 14:30

【摘要】：目的总结多系统萎缩(multiple system atrophy,MSA)以非运动症候和运动症候为首发症状的构成比和MSA非运动症候的具体症候构成比。方法选择MSA患者31例,其中MSA-P型18例,MSA-C型13例。进行详细病史记录和神经系统体检,记录运动症候及非运动症候具体表现及出现时间。结果 23例MSA以非运动症候首发。非运动症候的首发症状以快速眼动睡眠异常、排尿障碍、性功能障碍及直立性低血压常见。31例MSA患者均有非运动症候表现。以直肠功能障碍(93.5%)、排尿障碍(90.3%)、直立性低血压(64.5%)、睡眠呼吸暂停(61.3%)、快速眼动睡眠异常(48.4%)最为常见。MSA-P型与MSA-C型在年龄、性别、首发病程、就诊病程及非运动症候构成比较,差异无统计学意义(P0.05)。结论 MSA患者普遍存在自主神经功能障碍等非运动症候表现,且以首发症状多见。MSA-C型患者中以非运动症候起病较MSA-P型患者更为多见。
[Abstract]:Objective to summarize the composition ratio of non-motor symptom and motor symptom in (multiple system atrophy,MSA and the specific symptom ratio of non-motor symptom in MSA. Methods 31 patients with MSA were selected, including 18 patients with MSA-P type and 13 patients with MSA-C type. To record the detailed history and physical examination of nervous system and record the specific manifestation and time of motor symptom and non-motor symptom. Results 23 cases of MSA started with non-motor symptoms. The first symptoms of non-motor symptoms were abnormal rapid eye movement sleep, dysuria, sexual dysfunction and orthostatic hypotension. 31 patients with MSA had non-motor symptoms. Rectal dysfunction (93.5%), urination disorder (90.3%), orthostatic hypotension (64.5%), sleep apnea (61.3%), rapid eye movement sleep disorder (48.4%) were the most common. MSA-P type was compared with MSA-C type in age, sex, initial course, course of visit and non-motor symptoms. The difference was not statistically significant (P0.05). Conclusion Non-motor symptoms such as autonomic nervous dysfunction are common in patients with MSA, and non-motor symptoms are more common in patients with type .MSA-C than in patients with type MSA-P.
【作者单位】：第二军医大学海军临床医学院;海军总医院神经内科;
【基金】：首都卫生发展科研专项基金(2011-5031-02)
【分类号】：R741

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