Brain-derived neurotropic factor and GABAergic transmission

发布时间：2018-10-07 20:38

【摘要】：Neurotoxicity induced by stress,radiation,chemicals,or metabolic diseases,is commonly associated with excitotoxicity,oxidative stress,and neuroinflammation.The pathological process of neurotoxicity induces neuronal death,interrupts synaptic plasticity in the brain,and is similar to that of diverse neurodegenerative diseases.Animal models of neurotoxicity have revealed that clinical symptoms and brain lesions can recover over time via neuroregenerative processes.Specifically,brain-derived neurotropic factor(BDNF) and gamma-aminobutyric acid(GABA)-ergic transmission are related to both neurodegeneration and neuroregeneration.This review summarizes the accumulating evidences that suggest a pathogenic role of BDNF and GABAergic transmission,their underlying mechanisms,and the relationship between BDNF and GABA in neurodegeneration and neuroregeneration.This review will provide a comprehensive overview of the underlying mechanisms of neuroregeneration that may help in developing potential strategies for pharmacotherapeutic approaches to treat neurotoxicity and neurodegenerative disease.
[Abstract]:Neurotoxicity induced by stress,radiation,chemicals,or metabolic diseases,is commonly associated with excitotoxicity,oxidative stress,and neuroinflammation.The pathological process of neurotoxicity induces neuronal death,interrupts synaptic plasticity in the brain,and is similar to that of diverse neurodegenerative diseases.Animal models of neurotoxicity have revealed that clinical symptoms and brain lesions can recover over time via neuroregenerative processes.Specifically,brain-derived neurotropic factor(BDNF) and gamma-aminobutyric acid(GABA)-ergic transmission are related to both neurodegeneration and neuroregeneration.This review summarizes the accumulating evidences that suggest a pathogenic role of BDNF and GABAergic transmission,their underlying mechanisms,and the relationship between BDNF and GABA in neurodegeneration and neuroregeneration.This review will provide a comprehensive overview of the underlying mechanisms of neuroregeneration that may help in developing potential strategies for pharmacotherapeutic approaches to treat neurotoxicity and neurodegenerative disease.
【作者单位】： Departments
【基金】：supported by a grant from Wonkwang University in 2017
【分类号】：R741

【相似文献】

相关期刊论文 前10条

1 陈群,曾因明;Anisodamine protects against neuronal death following cerebral ischemia in gerbils[J];Chinese Medical Journal;2000年07期

2 张会欣;Effect of aminoguanidine on neuronal apoptosis induced by focal cerebral ischemia in rats[J];China Medical Abstracts;2005年03期

3 ;Role of alpha-synuclein in neuronal apoptosis induced by rotenone[J];Neural Regeneration Research;2006年01期

4 ;Cysteinyl leukotriene receptors CysLT_1 and CysLT_2 are upregulated in acute neuronal injury after focal cerebral ischemia in mice[J];Acta Pharmacologica Sinica;2006年12期

5 NG K Y;WONG Y H;WISE H;;Interactions between neuronal and non-neuronal cells in adult rat isolated dorsal root ganglion cells[J];沈阳药科大学学报;2008年S1期

6 ;Neural cell co-culture induced differentiation of bone marrow mesenchymal stem cells into neuronal-like cells[J];Neural Regeneration Research;2008年06期

7 ;Induced neuronal differentiation of neural stem cells by a combination of cytokines One-step versus two-step methods[J];Neural Regeneration Research;2009年11期

8 YE ZhiZhong;YE WeiBiao;DENG YuBin;WANG Jue;ZHOU GuangQian;ZHANG XiuQuan;;HIF-1-modified BMSCs improve migration and reduce neuronal apoptosis after stroke in rats[J];Chinese Science Bulletin;2013年Z2期

9 Hiroshi Kanno;;Regenerative therapy for neuronal diseases with transplantation of somatic stem cells[J];World Journal of Stem Cells;2013年04期

10 Javad Verdi;Seyed Abdolreza Mortazavi-Tabatabaei;Shiva Sharif;Hadi Verdi;Alireza Shoae-Hassani;;Citalopram increases the differentiation efficacy of bone marrow mesenchymal stem cells into neuronal-like cells[J];Neural Regeneration Research;2014年08期

相关会议论文 前10条

1 NG K Y;WONG Y H;WISE H;;Interactions between neuronal and non-neuronal cells in adult rat isolated dorsal root ganglion cells[A];两岸三地药理学与临床药理学术会议论文集[C];2008年

2 ;Hydrogen Sulfide: A Novel Endogenous Neuromodulator and Neuroprotectant[A];传承与发展，创湖南省生理科学事业的新高——湖南省生理科学会2011年度学术年会论文摘要汇编[C];2011年

3 ;Neuroprotective effects of BayK8644 against ischemic neuronal death in vivo and in vitro[A];中国神经科学学会第九届全国学术会议暨第五次会员代表大会论文摘要集[C];2011年

4 Ling WENG;Yung-Feng LIN;Alina L.LI;Chuan-En WANG;Sen YAN;Miao SUN;Marta A.GAERTIG;Naureen MITHA;Jun KOSAKA;Taketoshi WAKABAYASHI;Xing-Shun XU;Bei-Sha TANG;Shi-Hua LI;Xiao-Jiang LI;;Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation[A];中国神经科学学会第十届全国学术会议论文摘要集[C];2013年

5 肖东升;庄平;李建宇;张宇清;李勇杰;;Differential neuronal firing in the globus pallidus internus of patients with Parkinson's disease and dystonia[A];中华医学会神经外科学分会第九次学术会议论文汇编[C];2010年

6 ;Connexin 43 as stabilizer of astrocytes in stroke-like milieu gacilitates neuronal recovery mediated by inhibiting upregulation of ephrin-A4[A];中国药理学会第十一次全国学术会议专刊[C];2011年

7 Liang Wu;Yingdong Zhang;Jiangquan Shi;Jie Lu;Jiang Teng;;Candesartan cilexetil guards ER stress-induced dopaminergic neuronal apoptosis in a rotenone rat model of Parkinson's disease[A];2013年全国老年性痴呆与相关疾病学术会议论文汇编[C];2013年

8 ;The TRPC6 channels and neuronal survival[A];Proceedings of the 8th Biennial Conference of the Chinese Society for Neuroscience[C];2009年

9 Li Gao;Hua She;Wenming Li;Jinqiu Zhu;Dean P Jones;Zixu Mao;Guodong Gao;Qian Yang;;Oxidation of survival factor MEF2D in neuronal death and Parkinson's disease[A];中国神经科学学会第十届全国学术会议论文摘要集[C];2013年

10 ;20-hydroxyecdysoneprotects against oxidative stress- induced neuronal injuryand brain ischemic insult:involvement of NF-κ B/iNOSand ASK1-MKK4/7-JNK pathways and inhibition of ROS/RNS generation[A];中国医师协会神经外科医师分会第六届全国代表大会论文汇编[C];2011年

，

本文编号：2255594