大动脉粥样硬化型脑梗死患者血浆OPG水平与微栓子信号相关性研究
发布时间：2018-10-08 18:46
【摘要】：背景:动脉粥样硬化斑块的不稳定性和卒中的发生相关,微栓子信号是斑块不稳定的标志,我们已经确定血浆骨保护素(Osteoprotegerin,OPG)水平和卒中的发生相关,因此我们探讨血浆OPG水平在大动脉粥样硬化(large artery atherosclerosis,LAA)型脑梗死患者中是否与微栓子信号发生有关,同时进一步探讨血浆OPG能否作为评估入院时神经功能缺损严重性及微栓子信号发生的生物学标记物。方法:按照TOAST分型选取我院前循环大动脉粥样硬化型脑梗死患者127例和同期健康对照56例作为研究对象。对LAA型脑梗死患者于发病72小时内行经颅多普勒超声(transcranial Doppler sonography,TCD)监测病变侧微栓子,监测时间为1小时。根据监测结果,将LAA型脑梗死患者进一步分为微栓子阳性组和微栓子阴性组。同时记录患者入院时NIHSS(National Institutes of Health Stroke Scale)评分。根据NIHSS评分,将卒中患者进一步分为NIHSS Score≥6和NIHSS Score6组。采用酶联免疫吸附测定法(ELISA)分别检测所有研究对象血浆OPG水平,两组之间进行比较。结果:研究发现血浆OPG水平LAA型脑梗死患者明显高于健康对照组(1944.03±604.76 vs 1371.17±467.99pg/ml,p0.001),NIHSS Score≥6高于NIHSS Score6组(2260.11±658.21 vs 1841.96±552.39 pg/ml,p=0.001,),微栓子阳性组高于微栓子阴性组(2357.13±513.24 vs 1804.88±570.70pg/ml,p0.001)。用受试者曲线(ROC)分析血浆OPG预测神经功能缺损严重性的可行性,ROC曲线下面积是0.734,临界值是1998.44 pg/ml,敏感度80.6%,特异度65.6%。如果用血浆OPG的水平区分微栓子信号的发生,ROC曲线下面积0.766,临界值2107.91pg/ml,敏感度68.8%,特异度73.7%。结论:血浆OPG水平和卒中的严重性及微栓子信号的发生明显相关,血浆OPG也许能够作为神经功能缺损严重性及微栓子信号发生的一个生物学标志物。
[Abstract]:Background: the instability of atherosclerotic plaques is associated with the occurrence of stroke. Microemboli signal is a marker of plaque instability. We have identified a correlation between plasma osteoprotegerin (Osteoprotegerin,OPG) levels and stroke. Therefore, we investigate whether plasma OPG levels are associated with microemboli signal in patients with large atherosclerotic (large artery atherosclerosis,LAA type cerebral infarction. At the same time, whether plasma OPG can be used as a biological marker for evaluating the severity of neurologic impairment and the occurrence of microemboli signal at admission. Methods: according to TOAST classification, 127 patients with anterior circulation atherosclerotic cerebral infarction and 56 healthy controls were selected. The microemboli were monitored by transcranial Doppler (transcranial Doppler sonography,TCD (TCD) within 72 hours after onset of LAA cerebral infarction, and the monitoring time was 1 hour. According to the monitoring results, the patients with LAA type cerebral infarction were further divided into microemboli positive group and microemboli negative group. At the same time, the NIHSS (National Institutes of Health Stroke Scale) score on admission was recorded. According to NIHSS score, stroke patients were further divided into NIHSS Score 鈮，
本文编号：2257869
[Abstract]:Background: the instability of atherosclerotic plaques is associated with the occurrence of stroke. Microemboli signal is a marker of plaque instability. We have identified a correlation between plasma osteoprotegerin (Osteoprotegerin,OPG) levels and stroke. Therefore, we investigate whether plasma OPG levels are associated with microemboli signal in patients with large atherosclerotic (large artery atherosclerosis,LAA type cerebral infarction. At the same time, whether plasma OPG can be used as a biological marker for evaluating the severity of neurologic impairment and the occurrence of microemboli signal at admission. Methods: according to TOAST classification, 127 patients with anterior circulation atherosclerotic cerebral infarction and 56 healthy controls were selected. The microemboli were monitored by transcranial Doppler (transcranial Doppler sonography,TCD (TCD) within 72 hours after onset of LAA cerebral infarction, and the monitoring time was 1 hour. According to the monitoring results, the patients with LAA type cerebral infarction were further divided into microemboli positive group and microemboli negative group. At the same time, the NIHSS (National Institutes of Health Stroke Scale) score on admission was recorded. According to NIHSS score, stroke patients were further divided into NIHSS Score 鈮，
本文编号：2257869
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