原发性干燥综合征合并周围神经病变的血清免疫学特点

发布时间：2018-10-09 15:04

【摘要】：目的分析原发性干燥综合征(p SS)合并周围神经病变的血清免疫学改变。方法按2010年中华医学会所推荐的诊断标准依据,由风湿免疫专科医师入选2011~2014年该院收治的p SS患者,由神经内科专科医师对患者进行体格检查及肌电图检查是否伴有周围神经病变分为2组。观察组:合并周围神经病变组;对照组:单纯p SS组。分析两组患者血清免疫学指标。结果共纳入观察组25例,对照组61例,p SS累及周围神经的比例为29.1%(25/86)。观察组血清肿瘤坏死因子(TNF)-α水平显著高于对照组(t=4.586,P0.001)。两组患者SSA及SSB阳性率并无显著差异(P0.05),但观察组患者SSA/SSB双阳性比率显著高于对照组(χ2=9.211,P=0.002)。结论 p SS患者有一定比例累及周围神经,合并周围神经病变的患者血清TNF-α水平及SSA/SSB双阳性比例增高。
[Abstract]:Objective to analyze the changes of serum immunology in patients with primary Sjogren's syndrome (p SS) complicated with peripheral neuropathy. Methods according to the diagnostic criteria recommended by the Chinese Medical Association in 2010, the patients treated with p SS from 2011 to 2014 were selected by rheumatoid immunologists. The patients were divided into two groups: physical examination and electromyography. The observation group was treated with peripheral neuropathy and the control group was treated with simple p SS. The serum immunological indexes of the two groups were analyzed. Results there were 25 cases in the observation group and 61 cases in the control group. The percentage of peripheral nerve involvement was 29.1% (25 / 86) in the control group. The serum levels of tumor necrosis factor (TNF)-伪 in the observation group were significantly higher than those in the control group (t = 4. 586, P 0. 001). There was no significant difference in the positive rates of SSA and SSB between the two groups (P0.05), but the double positive rate of SSA/SSB in the observation group was significantly higher than that in the control group (蠂 ~ 2 / 9.211P ~ (0.002). Conclusion there is a certain proportion of peripheral nerves involved in p SS patients. The serum TNF- 伪 level and SSA/SSB double positive ratio are increased in patients with peripheral neuropathy.
【作者单位】：湖北民族学院风湿性疾病发生与干预湖北省重点实验室;湖北民族学院附属民大医院神经内科;
【基金】：国家自然科学基金(No.81260172) 湖北省自然科学基金(No.2014CFB617) 风湿性疾病发生与干预湖北省重点实验室开放基金项目(No.OIR13017B)
【分类号】：R593.2;R747.9

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