脑卒中患者血清中氧化应激指标的检测及临床意义
发布时间：2018-10-14 13:02
【摘要】：目的探讨脑卒中患者血清中氧化应激指标水平的变化及其临床意义。方法采用酶联免疫吸附试验(ELISA)测定168例脑卒中患者[其中缺血性脑卒中(IS)86例、出血性脑卒中(ICH)82例]和93名健康体检者(正常对照组)血清8-羟基脱氧鸟苷酸(8-OHd G)、丙二醛(MDA)和谷胱甘肽过氧化物酶(GSH-Px)。结果 IS和ICH组血清8-OHd G水平{中位数(M)[四分位数间距(P25~P75)]}分别为17.4(8.3~32.1)、9.3(6.6~21.8)ng/m L,MDA水平[M(P25~P75)]分别为5.6(4.4~11.2)、7.2(5.5~13.0)ng/m L,均明显高于正常对照组[4.3(2.1~6.9)、2.5(1.1~4.5)ng/m L](P均0.05);GSH-Px水平[M(P25~P75)]分别为479.5(259.2~861.7)、277.3(128.6~379.6)ng/m L,明显低于正常对照组[751.2(567.2~904.7)ng/m L](P0.05)。IS组血清8-OHd G及GSH-Px水平明显高于ICH组(P0.05),而MDA水平2个组之间差异无统计学意义(P0.05)。脑卒中患者8-OHd G与MDA、GSH-Px呈正相关(r值分别为0.21、0.59,P0.01),GSH-Px与MDA无相关性(r=0.11,P0.05)。结论血清8-OHd G、MDA和GSH-Px是脑卒中患者发生氧化应激的灵敏指标。8-OHd G、GSH-Px水平与脑卒中病情密切相关,对脑卒中患者的鉴别诊断具有重要价值。
[Abstract]:Objective to investigate the changes and clinical significance of serum oxidative stress in stroke patients. Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect (IS) in 168 patients with cerebral apoplexy. The serum levels of 8-OHd G), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px) were measured in 82 patients with hemorrhagic stroke (ICH) and 93 healthy controls (normal control group). 缁撴灉 IS鍜孖CH缁勮娓，
本文编号：2270534
[Abstract]:Objective to investigate the changes and clinical significance of serum oxidative stress in stroke patients. Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect (IS) in 168 patients with cerebral apoplexy. The serum levels of 8-OHd G), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px) were measured in 82 patients with hemorrhagic stroke (ICH) and 93 healthy controls (normal control group). 缁撴灉 IS鍜孖CH缁勮娓，
本文编号：2270534
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