探讨TNF-α在痉挛型脑瘫中的异常表达及其临床意义
发布时间：2018-10-16 18:43
【摘要】：目的探讨肿瘤坏死因子α过度表达在痉挛型脑性瘫痪发病中的临床意义。 方法选择小龄和大龄痉挛型脑性瘫痪各27例作为观察组，同时设立小龄和大龄正常儿童对照组各14例。所有儿童均抽取外周静脉血3ml，并对观察组儿童进行粗大运动功能分级系统（GMFCS）评估及生活活动能力(ADL)评估，经综合康复治疗6个月后重新进行ADL评估一次。采用ELISA法检测血清TNF-α水平，后将不同年龄组脑瘫儿童及正常儿童的TNF-α水平进行比较，并将脑瘫儿童的TNF-α水平与其GMFCS级别及ADL改善程度进行相关性分析，使用SPSS13.0统计软件对数据进行统计分析。 结果观察组的小龄及大龄痉挛型脑瘫儿童血清TNF-α均较相应年龄组对照组升高，差异均有统计学意义(P＜0.01)；观察组内小龄痉挛型脑瘫儿童血清TNF-α较大龄痉挛型脑瘫儿童血清TNF-α水平升高，且差异有统计学意义(P＜0.01)，，而对照组内正常儿童的不同年龄段的血清TNF-α基本无差异；观察组即痉挛型脑性瘫痪患儿血清TNF-α水平较正常儿童增高，且差异有统计学意义(P＜0.01)；痉挛型脑性瘫痪患儿血清TNF-α水平与其功能障碍程度相关性不显著，但痉挛型双瘫及多瘫儿童的血清TNF-α水平与其功能障碍程度有明显相关性。同时痉挛型脑性瘫痪患儿血清TNF-α与其6个月康复训练后ADL改善程度明显相关。 结论TNF-α在痉挛型脑性瘫痪患儿体内持续过度表达，参与脑性瘫痪的后续脑损伤；痉挛型双瘫及多瘫患儿的血清TNF-α水平与其功能障碍程度有明显相关性；痉挛型脑性瘫痪患儿血清TNF-α水平与其6个月康复训练后ADL改善程度明显相关，血清TNF-α可能成为评估痉挛型脑性瘫痪严重程度的指标之一。
[Abstract]:Objective to investigate the clinical significance of tumor necrosis factor 伪 overexpression in spastic cerebral palsy. Methods 27 cases of spastic cerebral palsy of young age and 27 cases of old spastic cerebral palsy were selected as observation group, and 14 cases of young age and 14 cases of old normal children in control group were set up at the same time. The peripheral venous blood was extracted from all the children at 3 ml. The patients in the observation group were evaluated with (GMFCS) and (ADL) of gross motor function grading system. After 6 months of comprehensive rehabilitation treatment, the ADL was re-evaluated. Serum TNF- 伪 levels were measured by ELISA method. The TNF- 伪 levels in children with cerebral palsy and normal children of different age groups were compared, and the correlation between TNF- 伪 level and GMFCS grade and the improvement of ADL were analyzed. Use the SPSS13.0 statistical software to carry on the statistical analysis to the data. Results the serum TNF- 伪 of the young and older children with spastic cerebral palsy in the observation group was significantly higher than that in the control group (P < 0. 01). The level of serum TNF- 伪 in children with spastic cerebral palsy was significantly higher than that in control group (P < 0. 01), but there was no significant difference in serum TNF- 伪 between normal children and normal children in control group (P < 0. 01). The levels of serum TNF- 伪 in patients with spastic cerebral palsy were significantly higher than those in normal children (P < 0. 01), and there was no significant correlation between the level of serum TNF- 伪 and the degree of dysfunction in children with spastic cerebral palsy. However, the level of serum TNF- 伪 in children with spastic diplegia and polyplegia was significantly correlated with the degree of dysfunction. At the same time, serum TNF- 伪 was significantly correlated with the improvement of ADL after 6 months rehabilitation training in children with spastic cerebral palsy. Conclusion TNF- 伪 is continuously overexpressed in children with spastic cerebral palsy, which is involved in the subsequent cerebral injury of cerebral palsy, and the level of serum TNF- 伪 in children with spastic diplegia and polyplegia is significantly correlated with the degree of dysfunction. The level of serum TNF- 伪 in children with spastic cerebral palsy was significantly correlated with the improvement of ADL after 6 months rehabilitation training. Serum TNF- 伪 might be one of the indexes to evaluate the severity of spastic cerebral palsy.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.3
本文编号：2275285
[Abstract]:Objective to investigate the clinical significance of tumor necrosis factor 伪 overexpression in spastic cerebral palsy. Methods 27 cases of spastic cerebral palsy of young age and 27 cases of old spastic cerebral palsy were selected as observation group, and 14 cases of young age and 14 cases of old normal children in control group were set up at the same time. The peripheral venous blood was extracted from all the children at 3 ml. The patients in the observation group were evaluated with (GMFCS) and (ADL) of gross motor function grading system. After 6 months of comprehensive rehabilitation treatment, the ADL was re-evaluated. Serum TNF- 伪 levels were measured by ELISA method. The TNF- 伪 levels in children with cerebral palsy and normal children of different age groups were compared, and the correlation between TNF- 伪 level and GMFCS grade and the improvement of ADL were analyzed. Use the SPSS13.0 statistical software to carry on the statistical analysis to the data. Results the serum TNF- 伪 of the young and older children with spastic cerebral palsy in the observation group was significantly higher than that in the control group (P < 0. 01). The level of serum TNF- 伪 in children with spastic cerebral palsy was significantly higher than that in control group (P < 0. 01), but there was no significant difference in serum TNF- 伪 between normal children and normal children in control group (P < 0. 01). The levels of serum TNF- 伪 in patients with spastic cerebral palsy were significantly higher than those in normal children (P < 0. 01), and there was no significant correlation between the level of serum TNF- 伪 and the degree of dysfunction in children with spastic cerebral palsy. However, the level of serum TNF- 伪 in children with spastic diplegia and polyplegia was significantly correlated with the degree of dysfunction. At the same time, serum TNF- 伪 was significantly correlated with the improvement of ADL after 6 months rehabilitation training in children with spastic cerebral palsy. Conclusion TNF- 伪 is continuously overexpressed in children with spastic cerebral palsy, which is involved in the subsequent cerebral injury of cerebral palsy, and the level of serum TNF- 伪 in children with spastic diplegia and polyplegia is significantly correlated with the degree of dysfunction. The level of serum TNF- 伪 in children with spastic cerebral palsy was significantly correlated with the improvement of ADL after 6 months rehabilitation training. Serum TNF- 伪 might be one of the indexes to evaluate the severity of spastic cerebral palsy.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.3
【参考文献】
相关期刊论文 前10条
1 段军;芮芳;唐久来;吴德;杨李;倪坤;魏薇;;脑性瘫痪儿童临床分型与合并症的相关性分析[J];安徽医学;2011年01期
2 吴华超;吴耀初;陈珊红;陈俏倩;符有文;;小儿脑性瘫痪的CT和MR诊断[J];中国CT和MRI杂志;2012年05期
3 薛静;陈立章;薛蕾;周权;;小儿脑性瘫痪母亲妊娠期危险因素的Meta分析[J];中国当代儿科杂志;2013年07期
4 李湘云;宋宗先;栗艳芳;;小儿脑性瘫痪临床特征分析[J];中国实用神经疾病杂志;2012年04期
5 张兰亭;万明智;彭义成;万贻钦;吴洪亮;凌小鹏;;小儿脑性瘫痪分型的商榷[J];中国临床康复;2006年42期
6 毛英丽;贾飞勇;胡晓兰;秦丽霞;梁东;;脑性瘫痪的早期诊断及治疗[J];中国妇幼保健;2009年09期
7 陈秀洁;李树春;;小儿脑性瘫痪的定义、分型和诊断条件[J];中华物理医学与康复杂志;2007年05期
8 陆晴友;脑瘫的病因学研究[J];中国康复理论与实践;2003年03期
9 孙杨;文芳;姚汉云;郭焱;肖玲;程自立;万均成;;免疫炎性因子过度表达在脑性瘫痪发病机制中的作用[J];中国康复理论与实践;2006年02期
10 史惟;杨红;施炳培;王艺;王素娟;;国内外脑性瘫痪定义、临床分型及功能分级新进展[J];中国康复理论与实践;2009年09期
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