成人脑干胶质瘤预后的影响因素分析

发布时间：2018-10-23 17:26

【摘要】：目的：回顾性分析成人脑干胶质瘤的病例特点及临床预后,研究影响成人脑干胶质瘤预后的相关因素。 方法：对2007年3月—2012年3月在中南大学湘雅二医院被诊断为成人脑干胶质瘤患者52例患者诊断时的年龄、性别、诊断潜伏期、肿瘤分类、MR有无病灶对比度增强、是否手术及手术方式、病理分型、WHO分级、是否行放化疗、生存时间等资料进行收集、整理。首先分析52例患者的总生存率及上述单因素与生存时间的关系,然后将单因素中与预后相关的及临床上认为有意义的纳入多因素回归分析。 结果：1.在52例随访患者中,总的2年生存率为76.5%,中位生存年龄为61个月。2.单因素分析发现：52例患者诊断时的年龄在20-68岁之间(中位年龄31岁,大于40岁17例,小于40岁35例,)与患者的生存时间相关；诊断时的KPS评分(大于70分40例(76.9%),小于70分12例(23.1%))与生存时间相关；以及肿瘤的WHO分级(Ⅰ-Ⅱ级例37例,Ⅲ级9例,Ⅳ级6例)与患者生存时间相关。3.多因素COX回顾分析结果显示肿瘤的WHO分级、诊断时的KPS评分与预后相关。 结论：1.诊断时的KPS评分与成人脑干胶质瘤的预后相关,KPS评分大于70分的患者预后更好。2.成人脑干胶质瘤的病例分级与患者预后相关,病理级别低的患者预后明显好于病理级别高的患者。3.成人脑干胶质瘤患者诊断时的年龄可能与患者的预后相关,但需要更大样本量、前瞻性的研究证实其相关性。
[Abstract]:Objective: to retrospectively analyze the characteristics and clinical prognosis of adult brainstem glioma and to study the related factors affecting the prognosis of adult brainstem glioma. Methods: from March 2007 to March 2012, 52 patients with adult brainstem glioma were diagnosed in Xiangya Hospital of Central South University. The age, sex, latent period of diagnosis, tumor classification and contrast enhancement of MR were studied. Whether the operation and operation mode, pathological classification, WHO grading, whether chemotherapy and radiotherapy, survival time and other data collected, collated. The overall survival rate of 52 patients and the relationship between the above univariate factors and survival time were analyzed at first, and then the prognostic factors were included in the multivariate regression analysis. The result is 1: 1. In 52 patients followed up, the overall 2-year survival rate was 76. 5% and the median survival age was 61 months. Univariate analysis showed that the diagnosis age of 52 patients was between 20 and 68 years old (median age was 31 years old, 17 cases were over 40 years old and 35 cases were younger than 40 years old). The KPS score (> 70 in 40 cases (76.9%), less than 70 in 12 cases (23.1%) was correlated with survival time, and the WHO grade (grade 鈪，

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