重症肌无力患者血清Titin和RyR抗体的临床研究
发布时间：2018-10-23 20:44
【摘要】：目的：探讨血清Titin抗体和Ryanodine受体(RyR)抗体在重症肌无力(myasthenia gravis,MG),尤其是合并胸腺瘤MG(MGT)和晚发型MG诊断中的临床意义。 方法：采用酶联免疫吸附试验(ELISA),检测61例MG患者(胸腺瘤24例,胸腺增生6例,胸腺正常31例)和35例正常对照组患者(NC)的血清Titin抗体和RyR抗体。 结果：①MG组Titin抗体和RyR抗体阳性率分别为62.3%和49.2%,对照组两种抗体阳性率分别为11.4%和8.6%,MG组两种抗体阳性率均显著高于对照组,差异均有统计学意义(P0.05)；②合并胸腺瘤MG组患者Titin抗体阳性率(为83.3%)明显高于未合并胸腺瘤MG组阳性率(为48.6%),差异均有统计学意义(P0.05)；合并胸腺瘤MG组和未合并胸腺瘤MG组患者RyR抗体阳性率(分别为58.3%、43.2%)差异无统计学意义(P0.05)；③晚发型MG患者中Titin抗体和RyR抗体均有较高的阳性率(分别为80.0%和63.3%),明显高于早发型MG患者的阳性率(分别为45.2%和35.5%),差异均有统计学意义(P0.05)；④MG患者Titin抗体和RyR抗体水平与肌无力严重程度相关分析呈正相关(r分别为0.520和0.487,P0.001)。 结论：Titin抗体和RyR抗体检测有助于MG的诊断。在晚发型MG患者,Titin抗体和RyR抗体有较高阳性率。在合并胸腺瘤MG患者中,Titin抗体也有较高阳性率。Titin抗体和RyR抗体水平与MG患者肌无力严重程度呈正相关,对评价病情与预后均有帮助。
[Abstract]:Objective: to investigate the clinical significance of serum Titin antibody and Ryanodine receptor (RyR) antibody in the diagnosis of myasthenia gravis (myasthenia gravis,MG), especially with thymoma MG (MGT) and late-onset MG. Methods: the serum Titin and RyR antibodies of 61 patients with MG (24 thymoma, 6 thymic hyperplasia, 31 normal thymus) and 35 normal controls were detected by enzyme linked immunosorbent assay (ELISA),). Results: the positive rates of Titin antibody and RyR antibody in 1MG group were 62.3% and 49.2%, respectively. The positive rates of Titin antibody and RyR antibody in control group were 11.4% and 8.6%, respectively, which were significantly higher than those in control group (P0.05). 2the positive rate of Titin antibody in MG group with thymoma (83.3%) was significantly higher than that in MG group without thymoma (48.6%), the difference was statistically significant (P0.05). The positive rate of RyR antibody in patients with thymoma MG and MG without thymoma was 58.3% and 43.2%, respectively. There was no significant difference between the two groups (P0.05). The positive rates of Titin antibody and RyR antibody were 80.0% and 63.3% in patients with late-onset MG (80.0% and 63.3%, respectively), which were significantly higher than those in patients with early-onset MG (45.2% and 35.5%, respectively), the difference was statistically significant (P0.05). The levels of Titin antibody and RyR antibody were positively correlated with the severity of myasthenia in patients with 4MG (r = 0.520 and 0.487g P0.001, respectively). Conclusion: the detection of Titin antibody and RyR antibody is helpful for the diagnosis of MG. The positive rates of Titin antibody and RyR antibody were higher in late onset MG patients. In patients with thymoma MG, the positive rate of Titin antibody was also high. The levels of Titin antibody and RyR antibody were positively correlated with the severity of myasthenia in MG patients, which was helpful to evaluate the severity and prognosis of MG.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R746.1
本文编号：2290414
[Abstract]:Objective: to investigate the clinical significance of serum Titin antibody and Ryanodine receptor (RyR) antibody in the diagnosis of myasthenia gravis (myasthenia gravis,MG), especially with thymoma MG (MGT) and late-onset MG. Methods: the serum Titin and RyR antibodies of 61 patients with MG (24 thymoma, 6 thymic hyperplasia, 31 normal thymus) and 35 normal controls were detected by enzyme linked immunosorbent assay (ELISA),). Results: the positive rates of Titin antibody and RyR antibody in 1MG group were 62.3% and 49.2%, respectively. The positive rates of Titin antibody and RyR antibody in control group were 11.4% and 8.6%, respectively, which were significantly higher than those in control group (P0.05). 2the positive rate of Titin antibody in MG group with thymoma (83.3%) was significantly higher than that in MG group without thymoma (48.6%), the difference was statistically significant (P0.05). The positive rate of RyR antibody in patients with thymoma MG and MG without thymoma was 58.3% and 43.2%, respectively. There was no significant difference between the two groups (P0.05). The positive rates of Titin antibody and RyR antibody were 80.0% and 63.3% in patients with late-onset MG (80.0% and 63.3%, respectively), which were significantly higher than those in patients with early-onset MG (45.2% and 35.5%, respectively), the difference was statistically significant (P0.05). The levels of Titin antibody and RyR antibody were positively correlated with the severity of myasthenia in patients with 4MG (r = 0.520 and 0.487g P0.001, respectively). Conclusion: the detection of Titin antibody and RyR antibody is helpful for the diagnosis of MG. The positive rates of Titin antibody and RyR antibody were higher in late onset MG patients. In patients with thymoma MG, the positive rate of Titin antibody was also high. The levels of Titin antibody and RyR antibody were positively correlated with the severity of myasthenia in MG patients, which was helpful to evaluate the severity and prognosis of MG.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R746.1
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