扩散张量成像定量参数与脑胶质瘤病理参数的相关性

发布时间：2018-10-24 19:38

【摘要】：目的探讨磁共振扩散张量成像(DTI)的各向异性分数(FA)值、表观扩散系数(ADC)值与脑胶质瘤病理参数的相关性。方法选择2015年1月至2017年4月经宁夏医科大学总医院手术病理证实的脑胶质瘤患者58例,术前均行常规磁共振成像(MRI)和磁共振DTI检查,感兴趣区(ROI)选择瘤周水肿区、肿瘤实质区、脑脊液和正常大脑白质区,测量其FA值和ADC值,比较不同病理级别脑胶质瘤FA值和ADC值的差异。结果高级别组肿瘤实质区FA值和ADC值、Ki-67标记指数依次为(0.198±0.034)、(1 013.17±163.42)×10~(-6) mm~2/s和(12.81±3.49)%,与低级别组的(0.142±0.027)、(1 442.34±195.78)×10~(-6) mm~2/s和(1.82±1.12)%比较,差异有统计学意义(P0.05);不同ROI的FA值、ADC值整体比较均有统计学差异(P0.05),正常大脑白质、瘤周水肿区FA值高于脑脊液区,而ADC值低于脑脊液区(P0.05),正常大脑白质、瘤周水肿区和肿瘤实质区FA值、ADC值两两比较均有统计学差异(P0.05);肿瘤实质区FA值与世界卫生组织(WHO)分级呈正相关(r=0.586,P=0.032),Ki-67标记指数与WHO分级呈正相关(r=0.793,P=0.005),FA值与Ki-67标记指数呈正相关(r=0.647,P=0.026)。结论 DTI检查的FA值对评估肿瘤细胞恶性程度具有较高的价值,可为该病治疗方案的制定提供参考信息。
[Abstract]:Objective to investigate the correlation between anisotropic fraction (FA) value, apparent diffusion coefficient (ADC) value and pathological parameters of glioma in (DTI) of Mr diffusion imaging. Methods from January 2015 to April 2017, 58 patients with brain gliomas confirmed by operation and pathology in the General Hospital of Ningxia Medical University were examined by (MRI) and DTI before operation. (ROI) in the region of interest selected the edema area around the tumor. The FA and ADC values of tumor parenchyma, cerebrospinal fluid and normal white matter were measured, and the differences of FA and ADC in gliomas of different pathological grades were compared. Results the FA value and ADC value of tumor parenchyma in high grade group were (0.198 卤0.034), (1 013.17 卤163.42) 脳 10 ~ (-6) mm~2/s and (12.81 卤3.49)% respectively, compared with (0.142 卤0.027), (1 442.34 卤195.78) 脳 10 ~ (-6) mm~2/s and (1.82 卤1.12)% in low grade group. The difference was statistically significant (P0.05), the FA value and ADC value of different ROI were significantly different (P0.05), the FA value of normal white matter and edema area around tumor was higher than that of cerebrospinal fluid area, but the ADC value was lower than that of cerebrospinal fluid area (P0.05). There were significant differences in FA value and ADC value between peritumoral edema area and tumor parenchyma area (P0.05), FA value in tumor parenchyma area was positively correlated with WHO (WHO) grade (r = 0.586P0. 032), Ki-67 labeling index was positively correlated with WHO grade (r = 0. 793 P0. 005), FA value was positively correlated with Ki-67 marker index (r = 0. 647P0. 026). Conclusion the FA value of DTI is of great value in evaluating the malignancy of tumor cells, and it can provide reference information for the formulation of treatment plan for the disease.
【作者单位】：宁夏医科大学总医院放疗科;
【基金】：宁夏回族自治区科技支撑计划项目(No.2015BY071)
【分类号】：R445.2;R739.41

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