血管内皮生长因子促损伤脑内神经血管单元的重构

发布时间：2018-11-04 10:31

【摘要】：血管内皮生长因子(vascular endothelial growth factor,VEGF)最初被认为是调节血管内皮细胞通透性及血管增生的生物活性物质。后来发现,VEGF在脑内的神经细胞也有表达,并参与神经细胞的发育、轴突的生长和神经元细胞膜上离子通道功能的调节。VEGF对损伤脑具有抗凋亡等神经保护作用。此外,VEGF还具有促进损伤脑内神经元新生的作用和增强活化胶质细胞转分化为新生神经元的能力。现有的文献提示,VEGF在正常脑内能调节神经可塑性,在损伤的脑内能促进神经血管单元的重构和脑修复。本文重点阐述成年脑内VEGF对神经细胞的生物学效应及其对损伤脑的修复作用。深入研究VEGF的神经调节作用及其机制,有助于理解脑功能调节机制,研发脑保护和脑修复的新技术。
[Abstract]:Vascular endothelial growth factor (vascular endothelial growth factor,VEGF) was originally considered as a bioactive substance regulating vascular endothelial cell permeability and vascular proliferation. It was later found that VEGF was also expressed in brain neurons and involved in the development of nerve cells, the growth of axons and the regulation of ion channel function on neuronal cell membranes. VEGF had neuroprotective effects on brain injury, such as anti-apoptosis. In addition, VEGF can promote the regeneration of injured neurons and enhance the ability of activated glial cells to differentiate into new neurons. It has been suggested that VEGF can regulate neural plasticity in normal brain and promote the remodeling and repair of neurovascular units in injured brain. This paper focuses on the biological effects of VEGF in adult brain and its repair effect on injured brain. Further study on the neuroregulatory effects and mechanisms of VEGF is helpful to understand the mechanism of brain function regulation and to develop new techniques for brain protection and brain repair.
【作者单位】：复旦大学基础医学院医学神经生物学国家重点实验室和神经生物学系;复旦大学上海医学院华山医院神经外科;复旦大学老年医学研究中心上海市老年医学临床重点实验室;
【基金】：supported by grants from the National Natural Science Foundation of China (No. 81030020 and 81571197).
【分类号】：R741

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