急性脑梗死血浆脂蛋白a及颈动脉粥样硬化斑块的关系探讨

发布时间：2018-11-07 20:36

【摘要】：目的探讨急性脑梗死患者血浆脂蛋白a及其颈动脉粥样硬化斑块的关系。方法选择2015年1月至2016年3月收治我院神经内科的急性脑梗死病人90例,入院后给予颈动脉彩色多普勒超声检查,根据检查结果分为有斑块组(52例)和无斑块组(38),两组间一般资料比较差异无统计学意义(P0.05),具有可比性。所有患者入院后抽血化验空腹血糖、胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、脂蛋白a、纤维蛋白原,进行比较并做相关分析。结果有斑块组总胆固醇、低密度脂蛋白、脂蛋白a、纤维蛋白原均明显高于无斑块组(P0.05),差异有统计学意义;多因素logistic回归分析显示总胆固醇、低密度脂蛋白、脂蛋白a、纤维蛋白原均和颈动脉粥样硬化斑块形成有关(P均0.05);相关性分析显示脂蛋白a与总胆固醇、低密度脂蛋白、纤维蛋白原无相关性(r=0.167、0.196、0.158,P=0.103、0.235、0.129)。结论脂蛋白a是颈动脉粥样硬化斑块形成的独立的危险因素,导致急性脑梗死的发生。
[Abstract]:Objective to investigate the relationship between plasma lipoprotein a and carotid atherosclerotic plaque in patients with acute cerebral infarction. Methods from January 2015 to March 2016, 90 patients with acute cerebral infarction admitted to our hospital from January 2015 to March 2016 were examined by carotid color Doppler ultrasound. According to the results, they were divided into plaque group (52 cases) and non-plaque group (38 cases). There was no significant difference in general data between the two groups (P0.05), which was comparable. Fasting blood glucose, cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, lipoprotein a, fibrinogen were compared and analyzed. Results Total cholesterol, low density lipoprotein, lipoprotein a and fibrinogen in plaque group were significantly higher than those in no plaque group (P0.05). Multivariate logistic regression analysis showed that total cholesterol, low density lipoprotein, lipoprotein a and fibrinogen were associated with carotid atherosclerotic plaque formation (all P 0. 05). There was no correlation between lipoprotein a and total cholesterol, low density lipoprotein, fibrinogen (r = 0.167). Conclusion Lipoprotein a is an independent risk factor for the formation of carotid atherosclerotic plaque, leading to acute cerebral infarction.
【作者单位】：内蒙古自治区包头市第四医院神经内科;内蒙古自治区包头市包钢三医院神经内科;
【分类号】：R743.33

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