帕金森病患者血清维生素D水平与不同认知域的临床观察

发布时间：2018-11-12 13:11

【摘要】：目的观察帕金森病(PD)患者血清维生素D水平和不同认知域的情况,评估血清维生素D水平与PD患者不同认知域的相关性。方法选择77例PD患者及同期34名健康对照者,检测空腹血清维生素D水平,采用认知功能相关量表对PD患者、健康对照者进行认知功能评分,同时进行PD患者运动功能和抑郁程度评分。结果 PD患者的血清维生素D水平较健康对照组的明显降低(t=-3.154,P=0.002)。PD痴呆组和非痴呆组的MMSE评分及蒙特利尔认知评估量表评分较健康对照组的明显降低(均P0.05)。PD痴呆组、PD非痴呆组与健康对照组相比,在多项认知功能领域评分有明显差异(均P0.05)。PD患者血清维生素D水平与病程和Hoehn-Yahr分期有显著负相关性(r_1=-0.372,P_1=0.002;r_2=-0.292,P_2=0.010)。PD非痴呆组的血清维生素D水平分别与听觉词语学习测试中即刻回忆、短延迟记忆、长延迟记忆(P_1=0.005;P_2=0.007;P_3=0.014)具有显著正相关性。结论 PD患者血清维生素D水平较正常人群明显降低,血清维生素D水平与PD患者的疾病病程、严重程度呈显著负相关,与PD非痴呆患者的记忆功能呈显著正相关,血清维生素D水平对于非痴呆PD患者的记忆功能具有一定的影响。
[Abstract]:Objective to investigate the relationship between serum vitamin D levels and different cognitive domains in patients with Parkinson's disease (PD) and to evaluate the correlation between serum vitamin D levels and different cognitive domains in patients with PD. Methods the fasting serum vitamin D levels were measured in 77 patients with PD and 34 healthy controls in the same period. Cognitive function scale was used to evaluate the cognitive function of PD patients and healthy controls. At the same time, the motor function and depression degree of patients with PD were evaluated. Results the serum vitamin D level in PD patients was significantly lower than that in the healthy control group (t = -3.154). The MMSE scores and the Montreal Cognitive Assessment scale scores in P0. 002). PD dementia group and non dementia group were significantly lower than those in the healthy control group (P0.05) in). PD dementia group, PD non dementia group and healthy control group. There was significant difference in scores in multiple cognitive functional areas (P0.05). There was a negative correlation between serum vitamin D level and course of disease and Hoehn-Yahr stage in patients with). PD (r1hl-0.372P10.002). The levels of serum vitamin D in the patients with non-dementia for r2mg-0.292). PD were compared with immediate memory, short delayed memory and long delayed memory (P _ (1) 0. 005) and P _ (20.007) in the auditory word learning test. P30.014) there was a significant positive correlation. Conclusion the serum vitamin D level in PD patients was significantly lower than that in normal controls. The serum vitamin D level was negatively correlated with the disease course and severity in PD patients, and positively correlated with the memory function of PD non-dementia patients. Serum vitamin D level has a certain effect on memory function in patients with non-dementia PD.
【作者单位】：苏州大学附属第二医院神经内科;
【基金】：苏州市卫生局科教兴卫青年科技项目(KJXW-2014012) 苏州市科技发展计划指导项目(SYSD2014088)
【分类号】：R742.5

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