左乙拉西坦添加治疗老年癫痫患者的临床观察

发布时间：2018-11-17 10:18

【摘要】：目的:考察左乙拉西坦添加治疗老年癫痫患者的临床效果及安全性。方法:将2014年1月-2016年1月于重庆市云阳县中医院就诊的老年癫痫患者88例按照随机数字表法分为观察组与对照组,各44例。对照组患者给予卡马西平+苯巴比妥常规抗癫痫治疗;观察组患者在对照组基础上加用左乙拉西坦片,初始剂量0.25g,后期根据患者病情可增至0.5g,bid。两组疗程均为6个月。观察两组患者的临床疗效、格拉斯哥昏迷评分法(GCS)评分、巴塞尔(Barthel)指数评分、蒙特利尔认知评估量表(Mo CA)评分和不良反应发生情况。结果:观察组患者的总有效率、控制率和Mo CA评分均显著高于对照组,差异均有统计学意义(P0.05)。两组患者治疗后的GCS和Barthel指数评分均明显高于治疗前,且观察组患者的2项评分均明显高于对照组,差异均有统计学意义(P0.05)。两组患者均未见明显不良反应发生。结论:采用左乙拉西坦添加治疗老年癫痫的疗效优于常规治疗方案,使患者的昏迷程度显著降低,日常生活能力与认知功能显著提高,且安全性较好。
[Abstract]:Objective: to investigate the clinical effect and safety of levoethylacetam in the treatment of senile epilepsy. Methods: 88 elderly epileptic patients from January 2014 to January 2016 were divided into two groups: observation group (n = 44) and control group (n = 44). The patients in the control group were given carbamazepine phenobarbital routine antiepileptic therapy, and the patients in the observation group were treated with levoethylacetam tablet on the basis of the control group, the initial dose was 0.25 g, and in the later stage, it could be increased to 0.5g bidbidin according to the patient's condition. The course of treatment was 6 months in both groups. The clinical efficacy, Glasgow coma score (GCS), Basel (Barthel) Index (Barthel), Montreal Cognitive Assessment scale (Mo CA) and adverse events were observed. Results: the total effective rate, control rate and Mo CA score in the observation group were significantly higher than those in the control group (P0.05). The GCS and Barthel index scores of the two groups after treatment were significantly higher than those before treatment, and the two scores of the observation group were significantly higher than those of the control group, the difference was statistically significant (P0.05). No significant adverse reactions occurred in both groups. Conclusion: the efficacy of levoethylacetam in the treatment of senile epilepsy is better than that of routine treatment. The degree of coma is significantly reduced, the ability of daily life and cognitive function are improved significantly, and the safety is better.
【作者单位】：重庆市云阳县中医院脑病科;重庆市涪陵中心医院神经内科;
【分类号】：R742.1

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