短暂性脑缺血发作进展为脑梗死的相关因素分析

发布时间：2018-11-21 18:45

【摘要】：目的探讨短暂性脑缺血发作(TIA)短期(1周)内进展为脑梗死的的危险因素。方法纳入54例短期内进展为脑梗死的TIA患者(进展组)和同期住院的54例未进展为脑梗死的TIA患者(对照组),在年龄、性别、高血压病史、糖尿病病史、卒中家族史、吸烟史、饮酒史、TIA发作次数、持续时间、入院时高血糖、入院后高血压、高血脂、纤维蛋白原(FIB)、超敏C反应蛋白(hs-CRP)、颈动脉斑块、颈动脉狭窄等16个因素进行t检验或χ~2检验,并用多元Logistic回归分析确定TIA进展为脑梗死的危险因素。结果2组间高血压病史、糖尿病病史、TIA发作次数、持续时间、入院时高血糖、hs-CRP、颈动脉斑块、颈动脉狭窄等8个因素差异有统计学意义(P0.01或P0.05),进一步多元Logistic回归分析显示,TIA发作次数、高血压病史、颈动脉斑块、持续时间、hs-CRP、糖尿病病史与脑梗死相关,是TIA短期内进展为脑梗死的主要危险因素。结论存在脑血管病危险因素的患者容易进展为脑梗死,TIA短期内进展为脑梗死是多种因素多种机制共同作用的结果。
[Abstract]:Objective to investigate the risk factors of transient ischemic attack (TIA) progression to cerebral infarction in the short term (1 week) of (TIA). Methods 54 TIA patients (progression group) with cerebral infarction and 54 TIA patients (control group) with no cerebral infarction in the same period were enrolled in this study. Age, sex, history of hypertension, history of diabetes, family history of stroke were included. History of smoking, history of drinking, number of TIA episodes, duration, admission hyperglycemia, postadmission hypertension, hyperlipidemia, fibrinogen (FIB), hypersensitive C-reactive protein (hs-CRP), carotid plaque, Sixteen factors, such as carotid artery stenosis, were tested by t test or 蠂 2 test. Multivariate Logistic regression analysis was used to determine the progression of TIA as a risk factor for cerebral infarction. Results there were significant differences in hypertension history, diabetes history, TIA attack times, duration, hyperglycemia at admission, hs-CRP, carotid plaque and carotid artery stenosis between the two groups (P0.01 or P0.05). Further multivariate Logistic regression analysis showed that the incidence of TIA, history of hypertension, carotid plaque, duration and history of hs-CRP, diabetes were associated with cerebral infarction, which were the main risk factors of cerebral infarction in the short term of TIA. Conclusion patients with risk factors of cerebrovascular disease tend to develop into cerebral infarction, and the short-term progression of TIA to cerebral infarction is the result of multiple factors and multiple mechanisms.
【作者单位】：江苏省张家港市澳洋医院神经内科;
【分类号】：R743.3

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