小脑顶核电刺激对脑微出血患者认知功能的影响

发布时间：2018-11-22 18:49

【摘要】：目的观察小脑顶核电刺激(FNS)对脑微出血(CMB)患者认知功能的影响。方法 35例CMB患者随机分为观察组及对照组。两组都给予内科常规药物治疗,观察组还接受FNS治疗。采用蒙特利尔认知评估量表(Mo CA)于治疗前、治疗15 d后对两组患者进行认知功能测评,并用MRI磁敏感加权成像对CMB病灶进行检查。结果 (1)FNS治疗后与治疗前观察组CMB病灶数目的比较差异无统计学意义(P0.05)。观察组治疗后CMB病灶数目与对照组治疗后的数目比较差异无统计学意义(P0.05);(2)药物治疗前、后对照组Mo CA 8个分项认知功能评分及总评分的比较差异无统计学意义(P0.05)。观察组FNS治疗后Mo CA 8个分项认知功能评分及总评分比治疗前的评分有提高(P0.05)。观察组治疗后Mo CA 8个分项认知功能评分及总评分比对照组治疗后的评分有提高(P0.05)。结论 FNS可改善CMB患者的认知功能,且安全,其有可能为CMB认知功能障碍患者提供1种辅助治疗手段。
[Abstract]:Objective to observe the effect of cerebellar fastigial nuclear stimulation (FNS) on cognitive function in (CMB) patients with microhemorrhage. Methods 35 patients with CMB were randomly divided into observation group and control group. Both groups were treated with routine medicine, while the observation group received FNS. The cognitive function of the two groups was evaluated with the Montreal Cognitive Assessment scale (Mo CA) before treatment and 15 days after treatment. The focus of CMB was examined with MRI magnetic sensitivity weighted imaging. Results (1) there was no significant difference in the number of CMB lesions between the FNS group and the observation group (P0.05). There was no significant difference in the number of CMB lesions between the observation group and the control group after treatment (P0.05). (2) before and after drug treatment, there was no significant difference in the scores of cognitive function and total score of 8 items of Mo CA in the control group (P0.05). The cognitive function score and total score of 8 items of Mo CA after FNS treatment in the observation group were higher than those before treatment (P0.05). The scores of cognitive function and total score of 8 items of Mo CA in the observation group were higher than those in the control group after treatment (P0.05). Conclusion FNS can improve the cognitive function of CMB patients, and it is safe. It may provide an adjuvant therapy for CMB patients with cognitive dysfunction.
【作者单位】：武汉大学人民医院神经内科;
【分类号】：R743.34

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