对比增强经颅多普勒超声对偏头痛与右向左分流相关性的福建地区单中心研究

发布时间：2018-11-25 12:49

【摘要】：目的观察偏头痛患者右向左分流(right-to-left shunt,RLS)的发生率,分析偏头痛与右向左分流的相关性。方法入选116例确诊为偏头痛的患者为病例组,75例健康志愿者为对照组,应用对比增强经颅多普勒超声(contrast-enhanced transcranial Doppler,c-TCD)诊断RLS并对分流量进行分级,分析两组的阳性率,进行统计分析。结果病例组中,RLS的阳性率为50.9%(59/116),其中,Ⅰ级分流35例(30.2%),Ⅱ级分流3例(2.6%),Ⅲ级分流7例(6.0%),Ⅳ级分流14例(12.1%)。对照组中,RLS的阳性率为30.6%(23/75),其中,Ⅰ级分流18例(24.0%),Ⅱ级分流1例(1.3%),Ⅲ级分流0例(0%),Ⅳ级分流4例(5.3%)。两组RLS总阳性率的比较,病例组的RLS总阳性率高于对照组,统计学有显著差异(P=0.006,χ~2=7.583);病例组的大量分流率显著高于对照组(P=0.011,χ~2=6.530),但两组的小量分流率比较无统计学差异(P=0.273,χ~2=1.199)。结论偏头痛与右向左分流存在相关,大量分流可能是偏头痛的病因,应引起临床重点关注。
[Abstract]:Objective to observe the incidence of right to left shunt (right-to-left shunt,RLS) in patients with migraine and to analyze the correlation between migraine and right left shunt. Methods RLS was diagnosed by contrast enhanced transcranial Doppler (contrast-enhanced transcranial Doppler,c-TCD) in 116 patients with migraine and 75 healthy volunteers as control group. The positive rate of the two groups was analyzed and statistical analysis was carried out. Results the positive rate of RLS was 50.9% (59 / 116), including 35 cases of grade 鈪，

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