5%与25%的人血白蛋白对老年脑出血危重患者血肿和神经功能缺损的影响
发布时间：2018-12-06 14:35
【摘要】：目的探究并分析5%与25%的人血白蛋白对老年性脑出血危重患者血肿与神经功能缺损的影响。方法选择老年性脑出血危重患者95例,按照随机数字表法将其分为观察组和对照组,其中观察组50例,对照组45例。对照组给予综合治疗(包括甘露醇、呋噻米、甘油果糖等脱水降颅压治疗)和5%人血白蛋白治疗,观察组在对照组综合治疗的基础上给予25%人血白蛋白治疗。治疗期间严密检测患者生命体征,治疗前后均对患者进行CT检查、神经功能缺损评分、疗效评定等操作。结果两组患者性别、年龄、出血部位等方面无明显差异(P0.05),具有可比性。观察组患者治疗前神经功能缺损评分为(21.56±7.35)分,对照组患者治疗前神经功能缺损评分为(20.45±6.32)分,两组无明显差异(t=0.712,P0.05)。两组患者治疗4 w后神经功能缺损评分分别为(8.67±4.78)分、(13.25±3.42)分,两组差异(t=4.571,P0.05);两组患者治疗后4 w神经功能缺损评分均明显低于治疗前(t=19.92,P0.05;t=8.31,P0.05)。观察组患者基本痊愈率(34.0%)明显高于对照组患者(13.3%,P0.05),且观察组患者总有效率明显高于对照组(P0.05)。两组患者治疗前颅内血肿体积分别为(18.3±8.2)ml、(18.4±7.5)ml(t=0.062,P0.05),二者无明显差异,治疗后两组患者血肿体积分别为(18.4±7.5)ml、(12.5±3.6)ml,差异显著(t=5.052,P0.05),且所有患者治疗后4 w血肿体积均明显小于治疗前(t=7.39,P0.05;t=4.34,P0.05)。结论 25%人血白蛋白较5%人血白蛋白更能有效较低颅内压,减轻颅内高压引起的并发症,有助于神经功能恢复,提高痊愈率。
[Abstract]:Objective to investigate and analyze the effects of 5% and 25% human albumin on hematoma and neurological impairment in elderly patients with intracerebral hemorrhage. Methods 95 patients with severe intracerebral hemorrhage were randomly divided into observation group (n = 50) and control group (n = 45). The control group was treated with comprehensive therapy (including mannitol, furosemide, glycerol fructose and other dehydration and lowering intracranial pressure) and 5% human serum albumin. The observation group was given 25% human serum albumin on the basis of comprehensive treatment in the control group. During the treatment, the vital signs of the patients were closely examined. The patients were examined with CT before and after treatment, the neurological deficit score and the evaluation of curative effect were performed. Results there was no significant difference in sex, age and bleeding location between the two groups (P0.05). The neurological deficit score before treatment was (21.56 卤7.35) in the observation group and (20.45 卤6.32) in the control group. There was no significant difference between the two groups (t _ (0.712) P 0.05). The neurological deficit scores of the two groups were (8.67 卤4.78) and (13.25 卤3.42) after 4 weeks of treatment, respectively, and the difference between the two groups was significant (P 0.05). The neurological deficit scores in both groups were significantly lower than those before treatment (t = 19.92, P 0.05, P = 8.31, P 0.05). The basic recovery rate of the observation group (34.0%) was significantly higher than that of the control group (13.3g / kg P0.05), and the total effective rate of the observation group was significantly higher than that of the control group (P0.05). The volume of intracranial hematoma in the two groups was (18.3 卤8.2) ml, (18.4 卤7.5) ml (t0. 062 ml,) before treatment, and there was no significant difference between the two groups. After treatment, the hematoma volume of the two groups was (18.4 卤7.5) ml,. (12.5 卤3.6) ml, was significantly different (P 0.05), and the hematoma volume in all patients was significantly lower than that before treatment (t = 7.39, P 0.05). (P 0.05). Conclusion 25% human serum albumin is more effective than 5% human serum albumin in lowering intracranial pressure, alleviating complications caused by intracranial hypertension, contributing to the recovery of nerve function and increasing recovery rate.
【作者单位】： 上海市第七人民医院;
【基金】：上海医院药学科研基金资助(No.2013-YY-01-02) 上海市第七人民医院“七院新星”人才培养项目(No.XX2012-026)
【分类号】：R743.34
[Abstract]:Objective to investigate and analyze the effects of 5% and 25% human albumin on hematoma and neurological impairment in elderly patients with intracerebral hemorrhage. Methods 95 patients with severe intracerebral hemorrhage were randomly divided into observation group (n = 50) and control group (n = 45). The control group was treated with comprehensive therapy (including mannitol, furosemide, glycerol fructose and other dehydration and lowering intracranial pressure) and 5% human serum albumin. The observation group was given 25% human serum albumin on the basis of comprehensive treatment in the control group. During the treatment, the vital signs of the patients were closely examined. The patients were examined with CT before and after treatment, the neurological deficit score and the evaluation of curative effect were performed. Results there was no significant difference in sex, age and bleeding location between the two groups (P0.05). The neurological deficit score before treatment was (21.56 卤7.35) in the observation group and (20.45 卤6.32) in the control group. There was no significant difference between the two groups (t _ (0.712) P 0.05). The neurological deficit scores of the two groups were (8.67 卤4.78) and (13.25 卤3.42) after 4 weeks of treatment, respectively, and the difference between the two groups was significant (P 0.05). The neurological deficit scores in both groups were significantly lower than those before treatment (t = 19.92, P 0.05, P = 8.31, P 0.05). The basic recovery rate of the observation group (34.0%) was significantly higher than that of the control group (13.3g / kg P0.05), and the total effective rate of the observation group was significantly higher than that of the control group (P0.05). The volume of intracranial hematoma in the two groups was (18.3 卤8.2) ml, (18.4 卤7.5) ml (t0. 062 ml,) before treatment, and there was no significant difference between the two groups. After treatment, the hematoma volume of the two groups was (18.4 卤7.5) ml,. (12.5 卤3.6) ml, was significantly different (P 0.05), and the hematoma volume in all patients was significantly lower than that before treatment (t = 7.39, P 0.05). (P 0.05). Conclusion 25% human serum albumin is more effective than 5% human serum albumin in lowering intracranial pressure, alleviating complications caused by intracranial hypertension, contributing to the recovery of nerve function and increasing recovery rate.
【作者单位】： 上海市第七人民医院;
【基金】：上海医院药学科研基金资助(No.2013-YY-01-02) 上海市第七人民医院“七院新星”人才培养项目(No.XX2012-026)
【分类号】：R743.34
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