血清白介素-27水平与视神经脊髓炎患者疾病严重程度的关系

发布时间：2018-12-13 22:13

【摘要】：目的检测视神经脊髓炎(neuromyelitis optica,NMO)患者与健康人血清中白介素27(interleukin-27,IL-27)水平,探讨其在NMO发病中的意义及其与疾病严重程度的相关性。方法采用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测39例NMO急性期患者与39例健康志愿者血清中IL-27水平,比较组间差异及分析NMO组血清IL-27水平与扩展残疾状况评分(expanded disability status scale,EDSS)、脊髓受累节段数、年复发率及水通道蛋白4(aquaporin-4,AQP-4)抗体滴度等临床指标的相关性。结果 NMO组血清IL-27水平较健康对照组(healthy controls,HCs)明显降低,差异具有统计学意义(P0.001),且NMO组患者血清IL-27水平与EDSS评分、脊髓受累节段数、随访2年平均复发率呈负相关(r=-0.439,P=0.010;r=-0.434,P=0.006;r=-0.451,P=0.031),而与AQP-4抗体滴度不存在相关性(r=-0.027,P=0.871)。多元回归分析显示血清IL-27水平与EDSS评分存在负相关性(B=-0.025,P=0.023)。结论 IL-27可能参与了NMO的发病过程,且与疾病严重程度负相关,同时对于疾病的预后具有一定影响。
[Abstract]:Objective to detect the level of interleukin-27 (interleukin-27,IL-27) in the serum of patients with optic neuromyelitis (neuromyelitis optica,NMO) and healthy subjects, and to explore its significance in the pathogenesis of NMO and its correlation with the severity of the disease. Methods Serum IL-27 levels in 39 NMO patients and 39 healthy volunteers were detected by enzyme linked immunosorbent assay (enzyme-linked immunosorbent assay,ELISA). Comparison and analysis of serum IL-27 level and extended disability score (expanded disability status scale,EDSS), number of spinal cord involvement segments, annual recurrence rate and aquaporin-4, 4 in NMO group Correlation of AQP-4 antibody titer and other clinical indexes. Results the serum IL-27 level in NMO group was significantly lower than that in healthy control group (healthy controls,HCs), the difference was statistically significant (P0. 001). The serum IL-27 level, EDSS score and the number of involved segments of spinal cord in NMO group were significantly lower than those in control group (P0. 001). There was a negative correlation between the average recurrence rate (r = 0.439) and the mean recurrence rate (P = 0.010). There was no correlation between the titer of AQP-4 antibody and the titer of AQP-4 antibody (r-0.027, P < 0. 871), but there was no correlation between the titer of AQP-4 antibody and the titer of AQP-4 antibody (r = 0. 434 4, P = 0. 006, P = 0. 451). Multiple regression analysis showed that there was a negative correlation between serum IL-27 level and EDSS score (BU-0. 025, P < 0. 023). Conclusion IL-27 may be involved in the pathogenesis of NMO, and is negatively correlated with the severity of the disease, and has a certain influence on the prognosis of the disease.
【作者单位】：天津市环湖医院;天津医科大学总医院神经内科;天津市神经病学研究所;天津医科大学总医院天津市神经病学研究所;
【基金】：国家自然科学基金面上项目(编号:81471221) 天津市应用基础与前沿技术研究计划(重点项目)(编号:15JCZDJC35700)
【分类号】：R744.52

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