老年脑出血患者血清乙酰肝素酶和血管内皮生长因子水平变化及其与出血量和出血部位的关系

发布时间：2018-12-16 21:57

【摘要】：目的探讨老年脑出血患者血清乙酰肝素酶(HPA)和血管内皮生长因子(VEGF)水平变化情况及其与出血量和出血部位的关系。方法选择老年脑出血患者50例作为脑出血组和健康体检老年人50例作为对照组,计算脑出血患者的脑出血量,采用酶联免疫吸附法(ELISA)测定两组血清HPA和VEGF水平。结果脑出血组脑出血1 d、脑出血1 w、脑出血2 w血清HPA和VEGF水平均显著高于对照组(P0.05),脑出血组脑出血1 w、脑出血2 w血清HPA和VEGF水平均显著高于脑出血1 d(P0.05),脑出血组脑出血2 w血清HPA和VEGF水平均显著高于脑出血1 w(P0.05)。脑出血量≤15 ml组患者各时点血清HPA和VEGF水平均显著低于脑出血15 ml组(P0.05)。丘脑出血组患者各时点血清HPA和VEGF水平和壳核出血组比较差异均无统计学意义(P0.05)。脑出血患者各时点血清HPA和VEGF水平均呈正相关(P0.05)。结论老年脑出血患者血清HPA和VEGF水平升高,随脑出血时间的延长,血清HPA和VEGF水平呈升高趋势,血清HPA和VEGF水平和脑出血量有关,和脑出血部位无相关性,血清HPA和VEGF水平呈正相关。
[Abstract]:Objective to investigate the changes of serum heparanase (HPA) and vascular endothelial growth factor (VEGF) levels in elderly patients with intracerebral hemorrhage. Methods 50 elderly patients with intracerebral hemorrhage and 50 healthy controls were selected as the control group. The amount of cerebral hemorrhage was calculated and the serum HPA and VEGF levels were measured by enzyme linked immunosorbent assay (ELISA). Results the levels of serum HPA and VEGF in cerebral hemorrhage group were significantly higher than those in control group at 1 day, 1 week and 2 weeks after intracerebral hemorrhage (P0.05). The levels of serum HPA and VEGF were significantly higher than that of intracerebral hemorrhage at 2 weeks (P0.05). The levels of serum HPA and VEGF in ICH group were significantly higher than those in ICH group at 2 weeks (P0.05). The levels of serum HPA and VEGF in patients with cerebral hemorrhage 鈮，

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