脑微出血和反社会人格障碍人群脑异常MRI研究
发布时间：2018-12-21 20:17
【摘要】：随着人们生活水平的上升以及脑科学研究手段的日益完善,对各种疾病的研究受到了越来越多的关注。论文分别对脑微出血疾病和反社会人格障碍进行了分析研究。对脑微出血疾病的研究,采用基于纤维束的空间统计方法,分析有脑微出血个体和无脑微出血个体的弥散张量图像,找出他们之间的结构差异。结果显示,脑微出血主要损伤右侧神经纤维。对反社会人格障碍人群的研究主要是采用局部一致性的方法,分析反社会人格障碍人群和健康人群的静息态功能磁共振数据,找出患者大脑异常活动区域,并根据发现的异常活动模式,运用模式分类方法评估其是否可以作为反社会人格障碍的生理标识。结果显示,与健康对照相比,反社会人格障碍人群主要在右小脑后叶、右脑额叶、枕叶和左脑颞叶的部分区域存在局部一致性异常活动。根据这一异常模式所做的分类表明,这一活动模型可以很好的区分反社会人格障碍个体和健康个体。因此,论文将增进对脑微出血疾病和反社会人格障碍神经病理机制的认知,为这种两种疾病的临床早期诊断和治疗提供一些重要参考信息。
[Abstract]:With the improvement of people's living standard and the improvement of the research methods of brain science, more and more attention has been paid to the research of various diseases. In this paper, microhemorrhage disease and antisocial personality disorder were studied. The spatial statistical method based on fiber bundle was used to analyze the diffused Zhang Liang images of individuals with and without intracerebral microhaemorrhage and to find out the structural differences between them. The results showed that cerebral microhemorrhage mainly damaged the right nerve fibers. The study of antisocial personality disorder is mainly to use the method of local consistency to analyze the resting functional magnetic resonance data of the antisocial personality disorder and healthy people, and to find out the abnormal regions of brain activity of the patients. According to the abnormal activity pattern found, the model classification method is used to evaluate whether it can be used as a physiological marker of antisocial personality disorder. The results showed that some areas of antisocial personality disorder in the posterior lobe of the right cerebellum, frontal lobe, occipital lobe and left temporal lobe of the right cerebellum showed abnormal activities. According to the classification of the abnormal model, the activity model can distinguish the antisocial personality disorder individuals from the healthy individuals. Therefore, this paper will enhance the understanding of the neuropathic mechanism of cerebral microhemorrhage and antisocial personality disorder, and provide some important reference information for the early diagnosis and treatment of these two diseases.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.34;TP391.41
本文编号：2389403
[Abstract]:With the improvement of people's living standard and the improvement of the research methods of brain science, more and more attention has been paid to the research of various diseases. In this paper, microhemorrhage disease and antisocial personality disorder were studied. The spatial statistical method based on fiber bundle was used to analyze the diffused Zhang Liang images of individuals with and without intracerebral microhaemorrhage and to find out the structural differences between them. The results showed that cerebral microhemorrhage mainly damaged the right nerve fibers. The study of antisocial personality disorder is mainly to use the method of local consistency to analyze the resting functional magnetic resonance data of the antisocial personality disorder and healthy people, and to find out the abnormal regions of brain activity of the patients. According to the abnormal activity pattern found, the model classification method is used to evaluate whether it can be used as a physiological marker of antisocial personality disorder. The results showed that some areas of antisocial personality disorder in the posterior lobe of the right cerebellum, frontal lobe, occipital lobe and left temporal lobe of the right cerebellum showed abnormal activities. According to the classification of the abnormal model, the activity model can distinguish the antisocial personality disorder individuals from the healthy individuals. Therefore, this paper will enhance the understanding of the neuropathic mechanism of cerebral microhemorrhage and antisocial personality disorder, and provide some important reference information for the early diagnosis and treatment of these two diseases.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.34;TP391.41
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