探讨在自发性颅内低压患者中脑脊液开放压的潜在影响因素
发布时间：2018-12-24 07:26
【摘要】：目的:自发颅内低血压(SIH)是一种由自发性脊髓脑脊液漏所引起的临床疾病,目前越来越多地被人们所认识。尽管以低脑脊液压力为主要特征,部分SIH患者的脑脊液开放压并不低。在这项研究中,我们旨在评估正常脑脊液开放压在SIH患者中所占的比例,并初步探讨SIH患者的脑脊液开放压的影响因素。方法:我们回顾了 206例在我院确诊的SIH患者,收集并分析其临床和影像学资料(包括人口学信息、体重指数、症状持续时间和脑部影像学结果)。采用单变量分析和多变量分析来识别脑脊液开放压的潜在影响因素。结果:本研究纳入的206例SIH患者中,共有114(55.3%)例患者的脑脊液开放压≤60mmH2O,90(43.7%)例患者的脑脊液开放压在60-200 mmH2O之间,2(1.0%)例患者的脑脊液开放压200mmH2O。单因素分析表明,症状持续时间(P0.001)、体重指数(BMI)(P0.001)和年龄(P=0.024)与脑脊液开放压呈正相关。然而,多因素分析显示,仅症状持续时间(P0.001)和BMI(P0.001)与脑脊液开放压之间有显著相关性。同时,多因素分析模型中得出相对较高的R2值(0.681)。结论:本研究表明,即使未出现脑脊液压力降低,SIH的诊断不应完全排除。BMI和症状持续时间可以影响SIH患者的脑脊液开放压大小,此外,仍然存在其他潜在因素需要进一步研究。
[Abstract]:Objective: spontaneous intracranial hypotension (SIH) is a clinical disease caused by spontaneous cerebrospinal fluid leakage. Although low cerebrospinal fluid pressure is the main characteristic, cerebrospinal fluid open pressure is not low in some SIH patients. In this study, we evaluated the proportion of open cerebrospinal fluid pressure in patients with SIH, and preliminarily investigated the factors affecting the open pressure of cerebrospinal fluid in patients with SIH. Methods: we reviewed 206 patients with SIH diagnosed in our hospital and collected and analyzed their clinical and imaging data (including demographic information, body mass index (BMI), duration of symptoms and brain imaging results). Univariate analysis and multivariate analysis were used to identify the potential factors of cerebrospinal fluid open pressure. Results: of the 206 patients with SIH, 114 (55.3%) had cerebrospinal fluid open pressure 鈮，
本文编号：2390341
[Abstract]:Objective: spontaneous intracranial hypotension (SIH) is a clinical disease caused by spontaneous cerebrospinal fluid leakage. Although low cerebrospinal fluid pressure is the main characteristic, cerebrospinal fluid open pressure is not low in some SIH patients. In this study, we evaluated the proportion of open cerebrospinal fluid pressure in patients with SIH, and preliminarily investigated the factors affecting the open pressure of cerebrospinal fluid in patients with SIH. Methods: we reviewed 206 patients with SIH diagnosed in our hospital and collected and analyzed their clinical and imaging data (including demographic information, body mass index (BMI), duration of symptoms and brain imaging results). Univariate analysis and multivariate analysis were used to identify the potential factors of cerebrospinal fluid open pressure. Results: of the 206 patients with SIH, 114 (55.3%) had cerebrospinal fluid open pressure 鈮，
本文编号：2390341
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