部分性癫痫合并阻塞性睡眠呼吸暂停低通气综合征患者的临床特征分析
发布时间：2018-12-30 10:45
【摘要】：目的:研究部分性癫痫合并阻塞性睡眠呼吸暂停低通气综合征(Obstructive sleep apnea syndrome,OSAHS)患者的临床特征。方法:随机选取2015年10月-2016年12月就诊于南昌大学第二附属医院的部分性癫痫患者68例为研究对象,所有研究对象均行视频多导睡眠监测(Polysomnograph,PSG)和同步视频脑电图(video-electroencephalogram,VEEG)监测,根据PSG监测结果判断有无OSAHS,将部分性癫痫患者分为癫痫合并OSAHS组(21例)和癫痫未合并OSAHS组(47例),研究部分性癫痫患者的OSAHS的发生率,通过比较两组间的年龄、性别、体重指数、发病年龄、病程时间、夜间发作、发作频率、使用抗癫痫药种数、发作间期癫痫样放电(interictal epileptiform discharges,IEDs),分析部分性癫痫合并OSAHS患者的临床特征。实验结果使用t检验、非参数检验、卡方检验及多元逐步线性回归。结果:1、68例部分性癫痫患者中达到OSAHS诊断标准的人数为21人(30.88%),轻度OSAHS患者13例(61.9%),中度OSAHS患者6例(28.6%),重度OSAHS患者2例(9.5%),其中男15例(71.4%),女6例(28.6%)。2、与癫痫未合并OSAHS组相比,癫痫合并OSAHS组平均血氧饱和度和最低血氧饱和度更低,差异具有统计学意义(P0.05)。3、癫痫合并OSAHS组与癫痫未合并OSAHS组相比,年龄、性别、发病年龄、IEDs差异具有统计学意义(P0.05),而体重指数、病程时间、夜间发作、发作频率、抗癫痫药物种数,两组之间差异无统计学意义(P0.05)。4、发病年龄和IEDs会对AHI产生正向影响,即发病年龄越大,IEDs阳性率越高,AHI也越高。结论:本研究部分性癫痫合并OSAHS的发生率为30.88%,主要的临床特征是中老年男性、发病年龄较大,IEDs阳性率更高。
[Abstract]:Objective: to study the clinical features of partial epilepsy with obstructive sleep apnea hypopnea syndrome (Obstructive sleep apnea syndrome,OSAHS). Methods: Sixty-eight patients with partial epilepsy who were admitted to Nanchang University second affiliated Hospital from October 2015 to December 2016 were randomly selected as subjects. All subjects were monitored by video polysomnography (Polysomnograph,). PSG) and synchronous video EEG (video-electroencephalogram,VEEG) monitoring. According to the results of PSG monitoring, the patients with partial epilepsy were divided into two groups: OSAHS group (21 cases) and non-epileptic OSAHS group (47 cases). To study the incidence of OSAHS in patients with partial epilepsy, we compared the age, sex, body mass index, onset age, duration of disease, nocturnal attack, frequency of seizure, number of antiepileptic drugs used between the two groups. Interictal epileptiform discharge (interictal epileptiform discharges,IEDs) was used to analyze the clinical features of partial epilepsy with OSAHS. T test, non-parametric test, chi-square test and multivariate stepwise linear regression were used. Results: (1) among 68 patients with partial epilepsy, 21 (30.88%) met the diagnostic criteria of OSAHS, 13 (61.9%) mild OSAHS, 6 (28.6%) moderate OSAHS, and 2 (9.5%) severe OSAHS. There were 15 males (71.4%) and 6 females (28.6%). Compared with the patients with epilepsy without OSAHS, the mean oxygen saturation and the lowest oxygen saturation were lower in the epilepsy with OSAHS group (P0.05). There were significant differences in age, sex, onset age and IEDs between OSAHS group and non-epileptic OSAHS group (P0.05), while body mass index, duration of disease, nocturnal attack, frequency of seizure, number of antiepileptic drugs were significant (P0.05). There was no significant difference between the two groups (P0.05). 4, onset age and IEDs will have a positive effect on AHI, that is, the older the age of onset, the higher the positive rate of IEDs and the higher the AHI. Conclusion: the incidence of partial epilepsy with OSAHS in this study is 30.88. The main clinical characteristics of this study are middle-aged and elderly men with older onset age and higher IEDs positive rate.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R766;R742.1
本文编号：2395475
[Abstract]:Objective: to study the clinical features of partial epilepsy with obstructive sleep apnea hypopnea syndrome (Obstructive sleep apnea syndrome,OSAHS). Methods: Sixty-eight patients with partial epilepsy who were admitted to Nanchang University second affiliated Hospital from October 2015 to December 2016 were randomly selected as subjects. All subjects were monitored by video polysomnography (Polysomnograph,). PSG) and synchronous video EEG (video-electroencephalogram,VEEG) monitoring. According to the results of PSG monitoring, the patients with partial epilepsy were divided into two groups: OSAHS group (21 cases) and non-epileptic OSAHS group (47 cases). To study the incidence of OSAHS in patients with partial epilepsy, we compared the age, sex, body mass index, onset age, duration of disease, nocturnal attack, frequency of seizure, number of antiepileptic drugs used between the two groups. Interictal epileptiform discharge (interictal epileptiform discharges,IEDs) was used to analyze the clinical features of partial epilepsy with OSAHS. T test, non-parametric test, chi-square test and multivariate stepwise linear regression were used. Results: (1) among 68 patients with partial epilepsy, 21 (30.88%) met the diagnostic criteria of OSAHS, 13 (61.9%) mild OSAHS, 6 (28.6%) moderate OSAHS, and 2 (9.5%) severe OSAHS. There were 15 males (71.4%) and 6 females (28.6%). Compared with the patients with epilepsy without OSAHS, the mean oxygen saturation and the lowest oxygen saturation were lower in the epilepsy with OSAHS group (P0.05). There were significant differences in age, sex, onset age and IEDs between OSAHS group and non-epileptic OSAHS group (P0.05), while body mass index, duration of disease, nocturnal attack, frequency of seizure, number of antiepileptic drugs were significant (P0.05). There was no significant difference between the two groups (P0.05). 4, onset age and IEDs will have a positive effect on AHI, that is, the older the age of onset, the higher the positive rate of IEDs and the higher the AHI. Conclusion: the incidence of partial epilepsy with OSAHS in this study is 30.88. The main clinical characteristics of this study are middle-aged and elderly men with older onset age and higher IEDs positive rate.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R766;R742.1
【参考文献】
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1 吕向裴;张成;马靖;宿利;贾鹏;罗义萍;魏淑敏;王广发;;柏林问卷在阻塞性睡眠呼吸暂停低通气综合征筛查中的应用价值[J];中华结核和呼吸杂志;2011年07期
，本文编号：2395475
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