氟哌噻吨美利曲辛片联合盐酸帕罗西汀治疗脑卒中后抑郁效果观察

发布时间：2019-01-12 15:15

【摘要】：目的探讨氟哌噻吨美利曲辛片(黛力新)联合盐酸帕罗西汀治疗脑卒中后抑郁症的临床效果。方法选取我院收治的脑卒中后抑郁症患者124例,随机分成观察组和对照组,各62例。两组均行脑卒中常规治疗,观察组在常规治疗基础上应用黛力新联合盐酸帕罗西汀治疗,对照组单纯应用黛力新治疗。连续治疗28d后,对比两组汉密顿抑郁量表评分(HAMD)、日常生活能力评分(ADL)和患者的治疗有效率和依从性。结果治疗前,两组各项评分无统计学意义,P0.05;治疗后,观察组HAMD评分明显低于对照组、ADL评分明显低于对照组,观察组治疗有效率为96.88%明显高于对照组的81.67%;临床治疗依从性为95.31%明显高于对照组的60.00%,两组各项评分比较均有统计学意义,P0.05。结论氟哌噻吨美利曲辛片联合盐酸帕罗西汀治疗脑卒中后抑郁症,可明显缓解抑郁症状,提高患者治疗依从性和生活质量,不良反应少,用药安全,比单纯应用黛力新治疗,效果更好,可临床推广应用。
[Abstract]:Objective to investigate the clinical effect of droperazothioate meritriaxine tablets (Delixin) combined with paroxetine hydrochloride in the treatment of post-stroke depression. Methods 124 patients with post-stroke depression were randomly divided into observation group and control group. The two groups were treated with routine stroke therapy, the observation group was treated with Delixine combined with paroxetine hydrochloride on the basis of routine treatment, and the control group was treated with Delycin alone. After 28 days of continuous treatment, the efficacy and compliance of the two groups were compared with the Hamilton Depression scale score (HAMD), the ADL score (ADL) and the effective rate of treatment. Results before treatment, there was no significant difference in scores between the two groups (P0.05; After treatment, the HAMD score and ADL score in the observation group were significantly lower than those in the control group, and the effective rate in the observation group was 96.88% higher than that in the control group (81.67%). The clinical treatment compliance was 95.31% significantly higher than that of the control group (60.005%). The scores of the two groups were significantly higher than those of the control group (P 0.05). Conclusion the treatment of post-stroke depression with droperazothioate metriaxine hydrochloride combined with paroxetine hydrochloride can significantly relieve the depression symptoms, improve the compliance and quality of life of the patients, have fewer adverse reactions, and is safer than that of the simple treatment of Delixine in the treatment of patients with post-stroke depression. The effect is better and can be popularized in clinic.
【作者单位】：河北邢台市人民医院;
【分类号】：R743.3;R749.4

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