人脑胶质瘤组织中Gab2、IgG、Integrinβ6的表达变化及其意义
发布时间：2019-01-24 15:12
【摘要】：目的观察人脑胶质瘤组织中Gab2、IgG、Integrinβ6的表达变化,并探讨其意义。方法采用免疫组化SP二步法检测55例份脑胶质瘤组织和20例份正常脑组织中的Gab2、IgG、Integrinβ6。分析脑胶质瘤组织中Gab2、IgG、Integrinβ6表达的相关性,及Gab2、IgG、Integrinβ6表达与脑胶质瘤患者临床病理参数的关系。结果脑胶质瘤组织中IgG、Gab2、Integrinβ6表达阳性分别为38(69.0%)、29(52.7%)、45(81.8%)例,正常脑组织中IgG、Gab2、Integrinβ6表达阳性分别为1(5.0%)、1(5.0%)、0例,脑胶质瘤组织中Gab2、IgG、Integrinβ6阳性表达率均高于正常脑组织(P均0.05)。脑胶质瘤组织中IgG与Gab2表达呈正相关(r=0.312 4,P0.05㖞,IgG与Integrinβ6表达呈正相关(r=0.398 8,P0.05㖞。脑胶质瘤未完整切除者Gab2、IgG、Integrinβ6阳性表达比例高于肿瘤完整切除者,肿瘤直径5 cm者Gab2、IgG、Integrinβ6阳性表达比例高于直径≤5 cm者,肿瘤分级Ⅲ~Ⅳ级者Gab2、IgG、Integrinβ6阳性表达比例高于Ⅰ~Ⅱ级者(P均0.05)。结论人脑胶质瘤组织中IgG、Gab2、Integrinβ6呈高表达,并与肿瘤直径、肿瘤完整切除情况和肿瘤分级有关。IgG、Gab2、Integrinβ6可能协同参与了脑胶质瘤的发生发展。
[Abstract]:Objective to observe the expression of Gab2,IgG,Integrin 尾 6 in human glioma and its significance. Methods Immunohistochemical SP two-step method was used to detect Gab2,IgG,Integrin 尾 6 in 55 cases of glioma and 20 cases of normal brain tissue. The relationship between the expression of Gab2,IgG,Integrin 尾 6 and the expression of Gab2,IgG,Integrin 尾 6 in gliomas was analyzed. Results the positive rates of IgG,Gab2,Integrin 尾 6 in gliomas were 38 (69.0%), 29 (52.7%) and 45 (81.8%), respectively. The positive expression of IgG,Gab2,Integrin 尾 6 in normal brain tissues was 1 (5.0%). 1 (5.0%), 0 cases, the positive expression rate of Gab2,IgG,Integrin 尾 6 in glioma tissue was higher than that in normal brain tissue (P 0.05). There was a positive correlation between the expression of IgG and Gab2 in glioma tissues (r = 0.312 4) and Integrin 尾 6 (r = 0.398 8 / P 0.05). The positive rate of Gab2,IgG,Integrin 尾 6 expression in patients with incomplete resection of gliomas was higher than that in patients with complete resection of tumors. The positive expression rate of Gab2,IgG,Integrin 尾 6 in patients with tumor diameter of 5 cm was higher than that in patients with diameter 鈮，
本文编号：2414581
[Abstract]:Objective to observe the expression of Gab2,IgG,Integrin 尾 6 in human glioma and its significance. Methods Immunohistochemical SP two-step method was used to detect Gab2,IgG,Integrin 尾 6 in 55 cases of glioma and 20 cases of normal brain tissue. The relationship between the expression of Gab2,IgG,Integrin 尾 6 and the expression of Gab2,IgG,Integrin 尾 6 in gliomas was analyzed. Results the positive rates of IgG,Gab2,Integrin 尾 6 in gliomas were 38 (69.0%), 29 (52.7%) and 45 (81.8%), respectively. The positive expression of IgG,Gab2,Integrin 尾 6 in normal brain tissues was 1 (5.0%). 1 (5.0%), 0 cases, the positive expression rate of Gab2,IgG,Integrin 尾 6 in glioma tissue was higher than that in normal brain tissue (P 0.05). There was a positive correlation between the expression of IgG and Gab2 in glioma tissues (r = 0.312 4) and Integrin 尾 6 (r = 0.398 8 / P 0.05). The positive rate of Gab2,IgG,Integrin 尾 6 expression in patients with incomplete resection of gliomas was higher than that in patients with complete resection of tumors. The positive expression rate of Gab2,IgG,Integrin 尾 6 in patients with tumor diameter of 5 cm was higher than that in patients with diameter 鈮，
本文编号：2414581
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