淋巴细胞亚群与帕金森病相关性的Meta分析

发布时间：2019-02-16 11:49

【摘要】：目的系统评价淋巴细胞亚群与帕金森病(PD)发病风险的关系。方法计算机检索Cochrane Library、Elsevier Science Direct、Pub Med/Medline、万方数据知识服务平台、中国知网、维普期刊资源整合服务平台,搜索已发表的T、B淋巴细胞亚群与PD相关性的病例对照研究,检索时限为建库至2016-09-30。按Cochrane系统评价方法筛选文献、提取资料并评价质量后,采用Rev Man 5.2软件进行Meta分析。结果纳入18篇病例对照研究,其中对照组609例,病例组770例。Meta分析结果显示,病例组较对照组CD_3~+T淋巴细胞计数降低[WMD=-6.48,95%CI(-8.41,-4.56),P0.001]、CD_4~+ T淋巴细胞计数降低[SMD=-0.99,95%CI(-1.27,-0.71),P0.001];病例组与对照组CD_8~+T淋巴细胞计数[SMD=-0.17,95%CI(-0.61,0.27),P=0.44]、B淋巴细胞计数[SMD=-0.25,95%CI(-0.61,0.12),P=0.19]比较,差异无统计学意义。结论 CD_3~+、CD_4~+T淋巴细胞可能与PD的发病风险相关,CD_8~+T淋巴细胞及B淋巴细胞亚群与PD的发病风险未见相关性。
[Abstract]:Objective to evaluate the relationship between lymphocyte subsets and the risk of Parkinson's disease (PD). Methods the Cochrane Library,Elsevier Science Direct,Pub Med/Medline, Wanfang data knowledge service platform, China Zhiwang, Weip periodical resources integration service platform were searched for the published case-control study on the correlation between T B lymphocyte subsets and PD. The time limit for retrieval is to build the database to 2016-09-30. The literature was screened according to the evaluation method of Cochrane system, the data was extracted and the quality was evaluated, and the Meta analysis was carried out with Rev Man 5.2 software. Results in 18 case-control studies, there were 609 cases in the control group and 770 cases in the case group. Meta analysis showed that the T lymphocyte count of CD_3~ in the case group was lower than that in the control group [WMD=-6.48,95%CI (-8.41 ~ 4.56)]. CD_4~ T lymphocyte count decreased [SMD=-0.99,95%CI (-1.27 -0.71), P0.001]; Compared with the control group, the CD_8~ T lymphocyte count [SMD=-0.17,95%CI (-0.61U 0.27), P < 0.44], B lymphocyte count (SMD=-0.25,95%CI (-0.61U 0.12), PU 0.19] in the case group were compared with those in the control group. The difference was not statistically significant. Conclusion CD_3~ and CD_4~ T lymphocytes may be associated with the risk of PD, but CD_8~ T lymphocytes and B lymphocyte subsets are not associated with the risk of PD.
【作者单位】：新疆医科大学第一附属医院神经内科;新疆医科大学第五附属医院神经内科;新疆医科大学第二附属医院;
【基金】：国家自然科学基金联合基金资助项目(U1503222)
【分类号】：R742.5

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