温阳复元方对缺血性中风恢复期的临床疗效及其作用机制研究

发布时间：2019-02-18 15:44

【摘要】：目的:本研究意在观察温阳复元方对缺血性中风恢复期的临床综合疗效及其对S-100B蛋白、神经肽Y、超敏C-反应蛋白的影响,以明确其疗效,并初步探讨其疗效机制,并为其临床应用打下坚实的基础。方法:选择符合缺血性中风恢复期诊断标准的患者80例,采取区组随机的原则分为治疗组(温阳复元方+西医常规治疗,简称温阳复元方组)、对照组(补阳还五汤+西医常规治疗,简称补阳还五汤组)各40例。治疗前及治疗4周后进行临床综合疗效以及实验室指标(S-100B蛋白、神经肽Y、超敏C-反应蛋白)评定,并前后进行统计学分析。结果:(1)、两组临床综合疗效比较:治疗组37例,基本痊愈7例,显效17例,有效10例,无效3例,总有效率91.89%;对照组36例,基本痊愈4例,显效12例,有效10例,无效10例,总有效率72.22%;两组比较差异具有统计学意义(P0.05),表明温阳复元方组效果优于补阳还五汤组。(2)、两组S-100B蛋白(S-100B protein)比较:两组患者治疗前血清中S-100B的含量比较,差异无统计学意义(P0.05);治疗后对比,两组之间存在差异性(P0.05),表明温阳复元方组下调S-100B的效果优于补阳还五汤组。(3)、两组神经肽Y(Neuropeptide Y,NPY)比较:两组患者治疗前血浆中NPY的含量比较,差异无统计学意义(P0.05);治疗后对比,两组之间存在差异性(P0.05),表明温阳复元方组下调血浆NPY的效果优于补阳还五汤组。(4)、两组超敏C-反应蛋白(high-sensitivity C-reactive protein,hs-CRP)比较:两组患者治疗前血清中hs-CRP的含量比较,差异无统计学意义(P0.05);治疗后对比,两组之间存在差异性(P0.05),表明温阳复元方组下调血清hs-CRP的效果优于补阳还五汤组。结论:温阳复元方联合西医常规疗法治疗缺血性中风恢复期疗效优于补阳还五汤联合西医常规疗法,初步揭示了温阳复元方的作用机制可能与下调S-100B、NPY、hs-CRP含量表达有关。
[Abstract]:Objective: To study the effect of Wenyang Fuyuan on the recovery of ischemic stroke and its effect on S-100B protein, neuropeptide Y and hypersensitive C-reactive protein. Methods: 80 patients with ischemic stroke recovery criteria were selected, and the random principle of the group was divided into treatment group (Wenyang Fuyuan + Western medicine general treatment, hereinafter referred to as" Wenyang Fuyuan "group), and the control group (Bu Yang, Wu Tang + Western medicine). 40 cases of each of the five decoction groups. The clinical comprehensive curative effect and the laboratory index (S-100B protein, neuropeptide Y and hypersensitive C-reactive protein) were evaluated before and after treatment for 4 weeks, and the statistical analysis was performed before and after treatment. Results: (1) In the treatment group, 37 cases were cured, 7 cases were cured, 17 cases were effective, 10 cases were effective, 3 cases were ineffective, the total effective rate was 91.89%, 36 cases in the control group, 4 cases were basically cured, 12 cases were effective, 10 cases were effective, and the total effective rate was 72.22%. The difference of the two groups was statistically significant (P <0.05), indicating that the effect of the Wenyang Fuyuan group was superior to that of the Wuyang Huanwu Decoction group. (2) The S-100B protein in the two groups was compared with that of S-100B protein in the two groups (P0.05). There was a difference between the two groups (P0.05). (3) There was no significant difference between the two groups of neuropeptide Y (NPY). There was no significant difference between the two groups (P0.05). There was a difference between the two groups after the treatment (P0.05). (4) The high-sensitivity C-reactive protein (hs-CRP) in the two groups showed no significant difference in the levels of hs-CRP in the two groups (P0.05). The results showed that the effect of reducing serum hs-CRP in Wenyang Fuyuan group was superior to that of the Wuyang Huanwu decoction group. Conclusion: The curative effect of Wenyang Fu-yuan combined with western medicine in the treatment of ischemic stroke is superior to that of the traditional Chinese medicine for the treatment of ischemic stroke. It is suggested that the mechanism of warming Yang Fu-yuan is related to the down-regulation of the content of S-100B, NPY, hs-CRP.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3

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