基于BCI-FES的肢体功能重建系统研究
发布时间：2019-03-06 09:40
【摘要】：随着社会老龄化问题日益凸显,脑卒中发病率也在逐年升高,临床上对于有效的脑卒中康复疗法有着迫切的需求。相对传统的机械式被动康复辅具,围绕功能性电刺激(FES)进行的肢体功能重建技术被普遍认为是一种有效的临床康复训练工具。但截至目前,该技术尚无法直接通过患者的自主意识实现运动控制,进而影响了肢体功能重建技术在我国临床康复方面的大规模应用和推广。本文将想象动作型脑-机接口(BCI)与FES技术结合,在体外重建脑卒中患者的运动神经通路,引入患者的主观意识来增加其在FES康复训练中的参与度,从而逐渐恢复肢体运动机能。研究中根据脑卒中康复的临床实际需求,设计并完成了符合YY0607-2007标准的神经肌肉电刺激器,在此基础上搭建了完整的BCI-FES系统,利用共空间模式(CSP)对右侧肢体想象动作的事件相关去同步(ERD)脑电信号进行特征提取,然后利用支持向量机(SVM)区分想象过程中的运动与静息状态,再将想象动作诱发电位驱动输出FES装置的控制命令,同时对分类阈值进行优化,降低其误触发率。2名健康被试与2名脑卒中偏瘫患者参与了异步脑-机接口临床实验。研究中利用临床康复量表、脑地形图和对侧占优系数作为评价手段,对脑卒中患者使用BCI-FES系统的康复效果进行了评价,结果发现患者临床量表得分有显著的提高。而从脑地形图与对侧占优系数来看,中风患者同侧占优现象慢慢消失,逐渐转变为对侧占优,这说明通过康复训练,患侧肢体映射的对侧脑区功能正在逐渐恢复,同时同侧脑区的运动皮层代偿功能也逐渐减弱。本研究临床试验结果证实脑卒中患者在经过文中设计的BCI-FES系统训练后,肢体运动功能可获得较为明显的恢复,这也体现了BCI-FES系统在脑卒中肢体功能重建中的巨大潜力。
[Abstract]:With the aging of society becoming increasingly prominent, the incidence of stroke is also increasing year by year. There is an urgent need for effective rehabilitation therapy for stroke. In contrast to the traditional mechanical passive rehabilitation aids, the technique of limb function reconstruction around functional electrical stimulation (FES) is generally regarded as an effective training tool for clinical rehabilitation. However, up to now, the technique has not been able to achieve motor control directly through the patient's autonomous consciousness, thus affecting the large-scale application and popularization of limb function reconstruction technology in clinical rehabilitation in China. In this paper, the imaginative brain-computer interface (BCI) and FES technique were combined to reconstruct the motor nerve pathway of stroke patients in vitro, and the subjective consciousness of the patients was introduced to increase their participation in FES rehabilitation training. As a result, the motor function of the limbs is gradually restored. According to the clinical needs of stroke rehabilitation, a neuromuscular electrical stimulator according to YY0607-2007 standard was designed and completed in this study, and a complete BCI-FES system was built on this basis. The event-related de-synchronous (ERD) EEG signals of the right limbs are extracted by using the common space model (CSP), and then the motion and rest states in the imagination process are distinguished by support vector machine (SVM). At the same time, the threshold of classification was optimized to reduce the mistriggering rate. Two healthy subjects and two stroke hemiplegic patients were involved in the asynchronous brain-computer interface (ACBI) clinical experiment. The control command of the output FES device was driven by the imaginary action evoked potential, and the classification threshold was optimized to reduce the mistriggering rate. In this study, clinical rehabilitation scale, brain map and contralateral dominance coefficient were used to evaluate the rehabilitation effect of BCI-FES system in stroke patients. The results showed that the scores of clinical scale of stroke patients were significantly improved. From the view of brain activity map and contralateral dominance coefficient, the phenomenon of ipsilateral dominance gradually disappeared and gradually turned to contralateral dominance, which indicated that the contralateral brain function of the affected limb mapping was gradually recovering through rehabilitation training. At the same time, the motor cortex compensation function of ipsilateral brain area also gradually weakened. The results of clinical trials show that the limb motor function of stroke patients can be recovered obviously after the training of BCI-FES system designed in this paper, which also shows the great potential of BCI-FES system in the reconstruction of limb function in stroke.
【学位授予单位】：天津大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3;R496
本文编号：2435414
[Abstract]:With the aging of society becoming increasingly prominent, the incidence of stroke is also increasing year by year. There is an urgent need for effective rehabilitation therapy for stroke. In contrast to the traditional mechanical passive rehabilitation aids, the technique of limb function reconstruction around functional electrical stimulation (FES) is generally regarded as an effective training tool for clinical rehabilitation. However, up to now, the technique has not been able to achieve motor control directly through the patient's autonomous consciousness, thus affecting the large-scale application and popularization of limb function reconstruction technology in clinical rehabilitation in China. In this paper, the imaginative brain-computer interface (BCI) and FES technique were combined to reconstruct the motor nerve pathway of stroke patients in vitro, and the subjective consciousness of the patients was introduced to increase their participation in FES rehabilitation training. As a result, the motor function of the limbs is gradually restored. According to the clinical needs of stroke rehabilitation, a neuromuscular electrical stimulator according to YY0607-2007 standard was designed and completed in this study, and a complete BCI-FES system was built on this basis. The event-related de-synchronous (ERD) EEG signals of the right limbs are extracted by using the common space model (CSP), and then the motion and rest states in the imagination process are distinguished by support vector machine (SVM). At the same time, the threshold of classification was optimized to reduce the mistriggering rate. Two healthy subjects and two stroke hemiplegic patients were involved in the asynchronous brain-computer interface (ACBI) clinical experiment. The control command of the output FES device was driven by the imaginary action evoked potential, and the classification threshold was optimized to reduce the mistriggering rate. In this study, clinical rehabilitation scale, brain map and contralateral dominance coefficient were used to evaluate the rehabilitation effect of BCI-FES system in stroke patients. The results showed that the scores of clinical scale of stroke patients were significantly improved. From the view of brain activity map and contralateral dominance coefficient, the phenomenon of ipsilateral dominance gradually disappeared and gradually turned to contralateral dominance, which indicated that the contralateral brain function of the affected limb mapping was gradually recovering through rehabilitation training. At the same time, the motor cortex compensation function of ipsilateral brain area also gradually weakened. The results of clinical trials show that the limb motor function of stroke patients can be recovered obviously after the training of BCI-FES system designed in this paper, which also shows the great potential of BCI-FES system in the reconstruction of limb function in stroke.
【学位授予单位】：天津大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3;R496
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