红细胞分布宽度在急性脑梗死动脉硬化评估中的应用

发布时间：2019-03-16 08:21

【摘要】：目的探讨急性脑梗死患者红细胞分布宽度(RDW)与颈部血管内中膜厚度及动脉硬化相关危险因素之间的相关性。方法对133例急性脑梗死住院患者,30名健康查体进行病例对照研究,急性脑梗死患者按RDW四分位数分为最低四分位数组34例,低四分位数组45例,高四分位数组24例,最高四分位数组30例。收集临床一般资料及脑血管病危险因素,测定空腹血糖、血脂、糖化血红蛋白、血红蛋白、平均RDW、平均红细胞体积(MCV)等,测量颈部血管超声内中膜厚度、血流速度等指标。结果急性脑梗死组与对照组对比,RDW(P=0.001)、颈内动脉内中膜厚度(P=0.008)差异显著;急性脑梗死各分组相关指标,同型半胱氨酸(P=0.04)各组存在统计学差异,其余指标无统计学意义;相关分析显示,RDW与舒张压(P=0.012)、同型半胱氨酸(P=0.004)、糖化血红蛋白(P=0.031)相关,颈动脉内中膜厚度与白细胞计数(P=0.024)、淋巴细胞计数(P=0.008)、纤维蛋白原(P=0.039)呈正相关。结论老年脑梗死患者的RDW与动脉硬化相关危险因素(舒张压、糖化血红蛋白、同型半胱氨酸)存在正相关。急性脑梗死四组间,随着RDW增加,IMT增加,动脉硬化程度加重,但差异无统计学意义。
[Abstract]:Objective to investigate the correlation between red blood cell distribution width (RDW) and carotid intima-media thickness (IMT) and risk factors of arteriosclerosis in patients with acute cerebral infarction (ACI). Methods A case-control study was conducted in 133 inpatients with acute cerebral infarction and 30 healthy controls. According to the RDWquartile, the patients with acute cerebral infarction were divided into the lowest quartile group (n = 34), the low quartile group (n = 45) and the high quartile group (n = 24). The highest quartile group included 30 cases. The clinical data and risk factors of cerebrovascular disease were collected, fasting blood glucose, blood lipid, glycosylated hemoglobin, mean RDW, mean red blood cell volume (MCV) and so on were measured, and the intima-media thickness of neck vessel was measured by ultrasound. Blood flow velocity and other indicators. Results in the acute cerebral infarction group, compared with the control group, the, RDW (P0. 001) and the intima-media thickness of the internal carotid artery (P < 0. 008) were significantly different. There were statistical differences in the indexes of each group of acute cerebral infarction, homocysteine (P0. 04), and the other indexes had no statistical significance. The correlation analysis showed that RDW was correlated with diastolic blood pressure (P = 0.012), homocysteine (P = 0.004), glycosylated hemoglobin (P = 0.031), carotid intima-media thickness (IMT) and white blood cell count (P = 0.024), lymphocyte count (P = 0.008). There was a positive correlation between fibrinogen (P < 0. 039). Conclusion there is a positive correlation between RDW and arteriosclerosis-related risk factors (diastolic blood pressure, glycosylated hemoglobin, homocysteine) in elderly patients with cerebral infarction. Among the four groups of acute cerebral infarction, with the increase of RDW and IMT, the degree of arteriosclerosis increased, but there was no significant difference.
【作者单位】：山东大学附属济南市中心医院;
【基金】：国家自然科学基金资助项目(No.81373635) 济南市科技发展国际合作项目(201212012)
【分类号】：R743.33

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