常德市汉族居民颈动脉粥样硬化斑块稳定性的相关因素分析
发布时间：2019-03-17 12:46
【摘要】：目的探讨影响常德市汉族居民颈动脉粥样硬化(CAS)斑块稳定性的相关因素。方法回顾性分析2014年1月至2014年12月期间在常德市第一人民医院门诊部就诊和体检中心进行体检的符合入组标准的对象794例,将入组对象分为稳定斑块组(353例)和不稳定斑块组(441例)。收集一般资料及生化检测结果。根据颈部血管彩色多普勒检查结果,对两组资料进行比较分析。结果单因素分析显示,两组在高血压、糖尿病、吸烟、年龄、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、纤维蛋白原(FIB)、C-反应蛋白(CRP)和同型半胱氨酸(Hcy)指标上差异有统计学意义(P0.05)。多因素Logistic回归分析显示,糖尿病(OR=3.115,95%CI:2.163~4.487,P=0.000)、高血压(OR=1.991,95%CI:1.429~2.772,P=0.000)、吸烟(OR=1.372,95%CI:1.001~1.879,P=0.049)、LDL-C(OR=1.308,95%CI:1.084~1.578,P=0.005)、FIB(OR=1.291,95%CI:1.055~1.580,P=0.013)、TC(OR=1.216,95%CI:1.001~1.477,P=0.049)、年龄(OR=1.033,95%CI:1.017~1.048,P=0.000)和Hcy(OR=1.031,95%CI:1.009~1.053,P=0.006)是CAS不稳定斑块形成的危险因素,差异具有统计学意义(P0.05)。HDL-C(OR=0.447,95%CI:0.270~0.740,P=0.002)是CAS不稳定斑块形成的保护因素,差异具有统计学意义(P0.05)。结论糖尿病、高血压、吸烟、LDL-C、FIB、TC、Hcy和年龄是常德市汉族居民CAS不稳定斑块的危险因素,HDL-C是常德市汉族居民CAS斑块稳定性的保护因素。
[Abstract]:Objective to investigate the influencing factors of (CAS) plaque stability of carotid atherosclerosis in Han nationality of Changde. Methods from January 2014 to December 2014, 794 patients who met the criteria of medical examination in the outpatient department and physical examination center of the first people's Hospital of Changde City were analyzed retrospectively. The subjects were divided into stable plaque group (353 cases) and unstable plaque group (441 cases). Collect general data and biochemical test results. According to the results of color Doppler, the data of the two groups were compared and analyzed. Results univariate analysis showed that in hypertension, diabetes, smoking, age, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fibrinogen (FIB),. There was significant difference between C-reactive protein (CRP) and homocysteine (Hcy) (P0.05). Multivariate Logistic regression analysis showed that diabetes mellitus (OR=3.115,95%CI:2.163~4.487,P=0.000), hypertension (OR=1.991,95%CI:1.429~2.772,P=0.000), smoking (OR=1.372,95%CI:1.001~1.879,P=0.049), LDL-C (OR=1.308,95%CI:1.084~1.578,P=0.005), FIB (OR=1.291,95%CI:1.055~1.580,P=0.013), TC (OR=1.216,95%CI:1.001~1.477,P=0.049), age (OR=1.033,95%CI:1.017~1.048,) P < 0. 000) and Hcy (OR=1.031,95%CI:1.009~1.053,P=0.006) were the risk factors of unstable plaque formation in CAS, the difference was statistically significant (P0.05). HDL-C (OR=0.447,95%CI:0.270~0.740,) P0. 002) was the protective factor of CAS unstable plaque formation, the difference was statistically significant (P0.05). Conclusion Diabetes mellitus, hypertension, smoking, LDL-C,FIB,TC,Hcy and age are risk factors for unstable plaque of CAS in Han nationality of Changde, and HDL-C is a protective factor of stability of CAS plaque of Han nationality of Changde.
【作者单位】： 常德市第一人民医院神经内科;中南大学湘雅医院神经内科;
【分类号】：R743.3
[Abstract]:Objective to investigate the influencing factors of (CAS) plaque stability of carotid atherosclerosis in Han nationality of Changde. Methods from January 2014 to December 2014, 794 patients who met the criteria of medical examination in the outpatient department and physical examination center of the first people's Hospital of Changde City were analyzed retrospectively. The subjects were divided into stable plaque group (353 cases) and unstable plaque group (441 cases). Collect general data and biochemical test results. According to the results of color Doppler, the data of the two groups were compared and analyzed. Results univariate analysis showed that in hypertension, diabetes, smoking, age, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fibrinogen (FIB),. There was significant difference between C-reactive protein (CRP) and homocysteine (Hcy) (P0.05). Multivariate Logistic regression analysis showed that diabetes mellitus (OR=3.115,95%CI:2.163~4.487,P=0.000), hypertension (OR=1.991,95%CI:1.429~2.772,P=0.000), smoking (OR=1.372,95%CI:1.001~1.879,P=0.049), LDL-C (OR=1.308,95%CI:1.084~1.578,P=0.005), FIB (OR=1.291,95%CI:1.055~1.580,P=0.013), TC (OR=1.216,95%CI:1.001~1.477,P=0.049), age (OR=1.033,95%CI:1.017~1.048,) P < 0. 000) and Hcy (OR=1.031,95%CI:1.009~1.053,P=0.006) were the risk factors of unstable plaque formation in CAS, the difference was statistically significant (P0.05). HDL-C (OR=0.447,95%CI:0.270~0.740,) P0. 002) was the protective factor of CAS unstable plaque formation, the difference was statistically significant (P0.05). Conclusion Diabetes mellitus, hypertension, smoking, LDL-C,FIB,TC,Hcy and age are risk factors for unstable plaque of CAS in Han nationality of Changde, and HDL-C is a protective factor of stability of CAS plaque of Han nationality of Changde.
【作者单位】： 常德市第一人民医院神经内科;中南大学湘雅医院神经内科;
【分类号】：R743.3
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