恒清汤对椎-基底动脉供血不足性眩晕作用的临床观察及其机制研究
发布时间：2019-04-16 17:19
【摘要】：目的:研究恒清汤对椎-基底动脉供血不足性(VBI)眩晕的临床疗效及其作用。方法:收集VBI眩晕的门诊及住院患者,将其随机分为治疗组(69)及对照组(67)。在基础治疗的基础下,治疗组采用恒清汤治疗,对照组采用盐酸氟桂利嗪胶囊(西比灵)治疗,疗程4周,共2个疗程。治疗前后,进行眩晕症状评分、欧洲眩晕量表及国际DHI眩晕障碍量表评分,经颅多普勒检测(TCD)及生化检查,计算动脉硬化指数(ASI)。结果:治疗组总有效率85.51%,对照组总有效率73.13%,两组比较有统计学差异(P0.05);两组治疗后,与对照组比较,治疗组的眩晕症状积分明显降低(P0.01),治疗前后差值明显降低(P0.01),EEV分值及DHI分值均明显降低(P均0.05),两侧VA和BA的Vp、Vm均升高(P0.05或P0.01),两侧VA和BA的PI和RI均下降(P0.05或P0.01),治疗组的TC下降(P0.05),HDL-C升高(P0.05),ASI明显下降(P0.01),全血高切、全血低切、血浆黏度、RBC聚集指标、纤维蛋白原均下降(P0.05,或P0.01)。结论:恒清汤对VBI眩晕患者有显著的疗效,其机制可能是通过提高VA和BA血流速度,降低总胆固醇、升高高密度脂蛋白,降低ASI,改善血流变指标来实现的。
[Abstract]:Objective: to study the clinical effect and effect of Hengqing decoction on (VBI) vertigo caused by vertebrobasilar insufficiency. Methods: the outpatients and inpatients with VBI vertigo were randomly divided into treatment group (69) and control group (67). On the basis of basic treatment, the treatment group was treated with Hengqing decoction, and the control group was treated with flunarizine hydrochloride capsule (sibelium hydrochloride) for 4 weeks for a total of 2 courses. Before and after treatment, vertigo symptom score, European vertigo scale and international DHI vertigo disorder scale were evaluated, (TCD) and biochemical examination were detected by transcranial Doppler, and (ASI). Of arteriosclerosis index was calculated. Results: the total effective rate of the treatment group was 85.51%, and the total effective rate of the control group was 73.13%, there was statistical difference between the two groups (P0.05). After treatment, the score of vertigo symptom in the treatment group was significantly lower than that in the control group (P0.01), and the difference before and after treatment was significantly lower (P0.01), EEV score and DHI score (both P 0.05). The Vp, of VA and BA on both sides was significantly decreased (P < 0.01). Vm increased (P0.05 or P0.01), PI and RI of both sides of VA and BA decreased (P0.05 or P0.01), TC of treatment group decreased (P0.05), HDL-C increased (P0.05), ASI significantly decreased (P0.01), whole blood cut high, The whole blood low shear rate, plasma viscosity, RBC aggregation index and fibrinogen were all decreased (P 0.05, or P0.01). Conclusion: Hengqing decoction has a significant therapeutic effect on patients with VBI vertigo, its mechanism may be achieved by increasing blood flow velocity of VA and BA, lowering total cholesterol, raising high density lipoprotein (HDL) and lowering ASI, to improve hemorheological indexes.
【作者单位】： 上海交通大学附属第六人民医院;上海市中医医院;
【基金】：上海市科委中医类引导项目(15401933300) 上海市卫计委项目(YSNXD-YL-YSZK013)
【分类号】：R743.3
本文编号：2458955
[Abstract]:Objective: to study the clinical effect and effect of Hengqing decoction on (VBI) vertigo caused by vertebrobasilar insufficiency. Methods: the outpatients and inpatients with VBI vertigo were randomly divided into treatment group (69) and control group (67). On the basis of basic treatment, the treatment group was treated with Hengqing decoction, and the control group was treated with flunarizine hydrochloride capsule (sibelium hydrochloride) for 4 weeks for a total of 2 courses. Before and after treatment, vertigo symptom score, European vertigo scale and international DHI vertigo disorder scale were evaluated, (TCD) and biochemical examination were detected by transcranial Doppler, and (ASI). Of arteriosclerosis index was calculated. Results: the total effective rate of the treatment group was 85.51%, and the total effective rate of the control group was 73.13%, there was statistical difference between the two groups (P0.05). After treatment, the score of vertigo symptom in the treatment group was significantly lower than that in the control group (P0.01), and the difference before and after treatment was significantly lower (P0.01), EEV score and DHI score (both P 0.05). The Vp, of VA and BA on both sides was significantly decreased (P < 0.01). Vm increased (P0.05 or P0.01), PI and RI of both sides of VA and BA decreased (P0.05 or P0.01), TC of treatment group decreased (P0.05), HDL-C increased (P0.05), ASI significantly decreased (P0.01), whole blood cut high, The whole blood low shear rate, plasma viscosity, RBC aggregation index and fibrinogen were all decreased (P 0.05, or P0.01). Conclusion: Hengqing decoction has a significant therapeutic effect on patients with VBI vertigo, its mechanism may be achieved by increasing blood flow velocity of VA and BA, lowering total cholesterol, raising high density lipoprotein (HDL) and lowering ASI, to improve hemorheological indexes.
【作者单位】： 上海交通大学附属第六人民医院;上海市中医医院;
【基金】：上海市科委中医类引导项目(15401933300) 上海市卫计委项目(YSNXD-YL-YSZK013)
【分类号】：R743.3
【相似文献】
相关期刊论文 前4条
1 郑祥理;林爱兰;陈洪;;促动脉硬化指数对脑梗死的临床价值研究[J];实用心脑肺血管病杂志;2013年11期
2 郭晓红;;2型糖尿病并发脑梗死患者血清高半胱氨酸、致动脉硬化指数和非HDL-C水平分析[J];临床和实验医学杂志;2013年16期
3 张瑞生;瞿卫;立彦;;2型糖尿病并发脑梗死患者血清高半胱氨酸、致动脉硬化指数和非HDL-C水平分析[J];临床检验杂志;2010年01期
4 ;[J];;年期
，本文编号：2458955
本文链接：https://www.wllwen.com/yixuelunwen/shenjingyixue/2458955.html
最近更新
教材专著
