月经性偏头痛患者的静息态功能磁共振研究

发布时间：2019-04-26 17:10

【摘要】：目的：影像学研究发现偏头痛患者大脑结构及任务相关脑功能发生改变，本研究采用静息态功能磁共振成像（resting-state functional magneticresonance imaging，rfMRI）技术研究月经性偏头痛患者发作间期静息状态下脑功能的改变，以便更好地认识其病理生理学机制。方法：对10例发作间期的月经性偏头痛患者和10例受教育程度、年龄相匹配的健康对照行rfMRI扫描，分别计算在三个不同频段下（slow-4:0.027-0.073Hz；slow-5:0.01-0.027Hz；典型频段：0.01-0.08Hz）的低频振幅（amplitude of low-frequency fluctuations，ALFF），得出两样本在典型频段下有显著统计学差异的脑区，并用方差分析得出两样本和两频段（slow-4、slow-5）之间的频率主效应、组间主效应和交互效应的脑区。结果： 1病例组和对照组ALFF值均显著增高的脑区有前后扣带回皮层、楔前叶、下顶叶、内侧前额叶皮质、岛叶等（P0.05Alphasim corrected）。 2病例组左侧额叶ALFF值较对照组显著增强（P0.05Alphasimcorrected）；病例组双侧枕叶、双侧丘脑ALFF值较对照组明显减弱（P0.05Alphasim corrected）。 3组间主效应显示与对照组相比，病例组左侧额叶ALFF值显著增强，，枕叶、双侧丘脑、左侧小脑ALFF值显著减弱（P0.05Alphasimcorrected）；频率主效应显示slow-4ALFF值明显高于slow-5的脑区在基底节、丘脑、楔前叶、扣带皮层、梭状回、中脑，低于slow-5的脑区有舌回、额下回、颞中回、腹内侧前额叶（P0.05Alphasim corrected）；存在交互作用的脑区是左侧岛叶及视觉皮层（P0.05Alphasim corrected）。结论：月经性偏头痛患者发作间期存在广泛的皮层及皮层下脑区的功能异常，并且异常的神经自发活动具有频率依赖性。
[Abstract]:Objective: imaging studies showed changes in brain structure and task-related brain function in migraine patients. Rest-state functional magnetic resonance imaging (resting-state functional magneticresonance imaging,) was used in this study. RfMRI) technique was used to study the changes of brain function during interictal rest in patients with menstrual migraine in order to better understand its pathophysiological mechanism. Methods: 10 interictal menstrual migraine patients and 10 age-matched healthy controls were scanned with rfMRI and calculated at three different frequency bands (slow-4:0.027-0.073Hz;). Slow-5:0.01-0.027Hz; The low frequency amplitude (amplitude of low-frequency fluctuations,ALFF) of the typical frequency band: 0.01-0.08Hz), the brain region with significant statistical difference between the two samples in the typical frequency band is obtained, and the two samples and the two frequency segments (slow-4,) are obtained by the analysis of variance. Slow-5) between the frequency main effects, the inter-group main effects and the interactive effects of the brain regions. Results: (1) there were anterior and posterior cingulate cortex, anterior cuneiform lobe, inferior parietal lobe, medial prefrontal cortex, island lobe and so on in the brain areas where ALFF was significantly increased in both the case group and the control group (P0.05Alphasim corrected). 2 the ALFF value of left frontal lobe in the case group was significantly higher than that in the control group (P0.05Alphasimcorrected), and the ALFF value in the bilateral occipital lobe and thalamus in the case group was significantly lower than that in the control group (P0.05Alphasimcorrected). Compared with the control group, the ALFF values in the left frontal lobe, occipital lobe, bilateral thalamus and left cerebellum were significantly decreased in the three groups (P0.05Alphasimcorrected), and the left frontal lobe in the case group was significantly higher than that in the control group (P < 0.05). The main effect of frequency showed that the value of slow-4ALFF was significantly higher than that of slow-5 in basal ganglia, thalamus, anterior wedge lobe, cingulate cortex, fusiform gyrus, midbrain, and lower than slow-5 had tongue gyrus, inferior frontal gyrus and middle temporal gyrus. Ventral prefrontal lobe (P0.05Alphasim corrected);) The interacting brain areas are the left insular lobe and visual cortex (P0.05Alphasim corrected). Conclusion: in patients with menstrual migraine, there are extensive functional abnormalities in cortex and subcortical region during interictal period, and abnormal spontaneous nerve activity is frequency-dependent.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R747.2;R445.2

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