促肾上腺皮质激素释放因子功能及其与帕金森病关系的研究进展
发布时间：2019-05-06 18:31
【摘要】：正帕金森病(Parkinson’s disease,PD)是一种常见的慢性神经系统退行性病变。临床上以静止性震颤、运动迟缓、肌强直和姿势步态障碍等运动症状为主要表现~([1])。主要病理改变是中脑黑质纹状体神经元退化、黑质致密部的多巴胺能神经元缺失和死亡以及残存的神经元胞质内出现嗜酸性包涵体,即路易小体~([2,3])。PD发病机制尚不明确,遗传、环境、老龄、氧化应激等均可能参与PD多巴胺能神经元的变性死
[Abstract]:Normal Parkinson's disease (Parkinson's disease,PD) is a common chronic neurodegenerative disease. The main motor symptoms such as quiescent tremor, motor retardation, muscular rigidity and postural gait disorder were the main manifestations of ~ ([1]). The main pathological changes were the degeneration of the striatal neurons in the substantia nigra, the loss and death of dopaminergic neurons in the substantia nigra dense part, and the appearance of eosinophil inclusion bodies in the remaining cytoplasm of the neurons. The pathogenesis of PD is not clear. Heredity, environment, aging, oxidative stress and so on may be involved in the degeneration and death of dopaminergic neurons in PD.
【作者单位】： 遵义医学院生理学教研室贵州省麻醉与器官功能保护重点实验室;
【基金】：国家自然科学基金(1460266) 教育部新世纪优秀人才计划(NCET-13-1070)
【分类号】：R742.5
，
本文编号：2470395
[Abstract]:Normal Parkinson's disease (Parkinson's disease,PD) is a common chronic neurodegenerative disease. The main motor symptoms such as quiescent tremor, motor retardation, muscular rigidity and postural gait disorder were the main manifestations of ~ ([1]). The main pathological changes were the degeneration of the striatal neurons in the substantia nigra, the loss and death of dopaminergic neurons in the substantia nigra dense part, and the appearance of eosinophil inclusion bodies in the remaining cytoplasm of the neurons. The pathogenesis of PD is not clear. Heredity, environment, aging, oxidative stress and so on may be involved in the degeneration and death of dopaminergic neurons in PD.
【作者单位】： 遵义医学院生理学教研室贵州省麻醉与器官功能保护重点实验室;
【基金】：国家自然科学基金(1460266) 教育部新世纪优秀人才计划(NCET-13-1070)
【分类号】：R742.5
，
本文编号：2470395
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