AIS病人颈动脉粥样硬化性斑块的组分特征分析

发布时间：2019-05-11 17:37

【摘要】：目的：分析颈内动脉系统AIS病人的颈动脉粥样硬化性斑块的组分特征,并初步探讨溃疡斑块、管腔狭窄程度、斑块体积、低回声斑块组分、高回声斑块组分等斑块组分特征之间的关系。 方法：收集于2008年1月-2014年1月期间连续收入我院治疗的颈内动脉系统AIS病人病历资料519例。根据高分辨率颈动脉超声检查结果,将存在颈动脉粥样硬化斑块的病人纳入实验,并统计颈动脉斑块的组分特征。如颈动脉管腔狭窄程度、颈动脉粥样硬化斑块体积、低回声斑块体积、高回声斑块体积,并利用逻辑回归分析方法分析统计学方法分析斑块组分特征。 结果：1、共有288例颈内动脉系统AIS病人检出颈动脉粥样硬化性斑块,其中49人检出溃疡斑块。与无颈动脉粥样硬化溃疡斑块组相比,颈动脉粥样硬化溃疡斑块组病人的管腔狭窄程度、斑块体积、低回声斑块组分体积、低回声斑块组分体积/斑块总体积百分比更高(P0.05)。采用逻辑回归分析方法分析,调整了年龄、性别和管腔狭窄程度等因素后,粥样硬化性斑块体积(OR值,1.11；95%CI,1.03-1.18)和低回声斑块体积/斑块体积百分比(0R值,2.06；95%CI,1.53-3.19)与溃疡斑块呈正相关,而高回声斑块体积/斑块体积百分比与斑块溃疡呈负相关(OR值,0.63；95%CI,0.42-0.87)。 2、按颈动脉狭窄程度将入组病人分为轻中度颈动脉狭窄组(狭窄程度50%,n=162)和重度颈动脉狭窄组(狭窄程度≥50%,n=126)。并分别对两组病人中颈动脉溃疡斑块与其它颈动脉斑块组分特征之间的关系行多因素分析：在轻中度狭窄病人中,低回声斑块体积/斑块体积百分比与溃疡斑块呈正相关(0R值,3.14；95%CI,1.82-5.35),而高回声斑块体积/斑块体积百分比与斑块溃疡呈负相关(OR值,0.41；95%CI,0.19-0.67)。 结论：高分辨率超声检测可以对颈动脉粥样硬化斑块易损性、不稳定性进行评估,对AIS病人颈动脉粥样硬化斑块的二级预防及危险因素分层管理和治疗具有指导意义。
[Abstract]:Objective: to analyze the component characteristics of carotid atherosclerotic plaques in patients with internal carotid artery system (AIS), and to explore the plaque size, plaque volume, and plaque components of ulcers, lumen stenosis, and hypoechoic plaques. The relationship between the characteristics of hyperechoic plaque components and other plaque components. Methods: from January 2008 to January 2014, 519 patients with AIS of internal carotid artery system who were admitted to our hospital from January 2008 to January 2014 were collected. According to the results of high resolution carotid ultrasound, the patients with carotid atherosclerotic plaques were included in the experiment, and the composition characteristics of carotid plaques were counted. For example, the degree of carotid lumen stenosis, carotid atherosclerotic plaque volume, hypoechoic plaque volume, hyperechoic plaque volume, and logical regression analysis were used to analyze the characteristics of plaque components. Results: 1. Carotid atherosclerotic plaques were detected in 288 patients with internal carotid artery system AIS, and ulcer plaques were detected in 49 of them. Compared with the group without carotid atherosclerosis ulcer plaque, the degree of lumen stenosis, plaque volume and hypoechoic plaque component volume in carotid atherosclerosis ulcer plaque group were significantly higher than those in carotid atherosclerosis ulcer plaque group. The percentage of hypoechoic plaque component volume / total plaque volume was higher (P 0.05). After adjusting the factors such as age, sex and lumen stenosis, the volume of atherosclerotic plaques (OR, 1.11) was analyzed by logical regression analysis. 95% CI, 1.03x1.18) and the percentage of low echo plaque volume / plaque volume (0R, 2.06); 95% CI1.53 鈮，

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