抗N-甲基-D-天冬氨酸受体脑炎27例分析
发布时间：2019-05-18 08:41
【摘要】：目的总结抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎患者的临床特征。方法收集收治的抗NMDAR脑炎患者的临床资料,总结分析其临床特征、辅助检查、治疗及预后。根据有无合并肿瘤将患者分为肿瘤组、无瘤组,对比分析两组之间的前驱及首发症状。结果共纳入27例抗NMDAR脑炎患者,男女比例为1∶1.7,发病年龄9~52岁,中位发病年龄为24岁。其中肿瘤组9例,均为女性,合并卵巢畸胎瘤;无瘤组18例。肿瘤组和无瘤组在前驱症状、首发症状方面的差异无统计学意义(P0.05)。大部分患者经免疫治疗及肿瘤切除后获得了较好的预后。结论抗NMDAR脑炎发病率并不低,其与畸胎瘤明显相关,需要引起神经内科及妇产科医生重视。对于急性起病,出现明显精神症状、癫痫发作的年轻女性患者,应高度警惕抗NMDAR脑炎的可能性,并积极通过影像学手段筛查肿瘤。
[Abstract]:Objective to summarize the clinical features of patients with anti-N-methyl-D-aspartate receptor (NMDAR). Methods the clinical data of patients with anti-NMDAR meningitis were collected, and their clinical features, auxiliary examination, treatment and prognosis were summarized and analyzed. According to the presence or absence of tumor, the patients were divided into tumor group and tumor-free group, and the prodromes and first symptoms between the two groups were compared and analyzed. Results A total of 27 patients with anti-NMDAR meningitis were enrolled in this study. the ratio of male to female was 1 鈮，
本文编号：2479853
[Abstract]:Objective to summarize the clinical features of patients with anti-N-methyl-D-aspartate receptor (NMDAR). Methods the clinical data of patients with anti-NMDAR meningitis were collected, and their clinical features, auxiliary examination, treatment and prognosis were summarized and analyzed. According to the presence or absence of tumor, the patients were divided into tumor group and tumor-free group, and the prodromes and first symptoms between the two groups were compared and analyzed. Results A total of 27 patients with anti-NMDAR meningitis were enrolled in this study. the ratio of male to female was 1 鈮，
本文编号：2479853
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