铁蛋白在高血压脑出血后血肿周围脑水肿中的作用及机制
发布时间：2019-05-18 20:23
【摘要】：目的探讨血清铁蛋白与高血压脑出血后血肿周围脑水肿的关系,并分析其在血肿周围脑水肿发生中发挥的作用及机制。方法采集2014年1月~2015年6月于北京丰台右安门医院神经外科住院治疗的38例高血压脑出血患者的临床资料和实验室数据,所有患者均在入院时及入院72 h后行血清铁蛋白及头颅CT检查,计算入院时及入院72 h后血肿体积、脑水肿总体积及经校正后的相对水肿体积。采用单因素方差分析与脑出血后血肿周围脑水肿相关的因素,采用Spearman相关系数分析血清铁蛋白与相对血肿周围脑水肿体积的相关性。结果入院当天患者脑血肿体积为(13.25±5.54)cm3,入院72 h后脑血肿体积为(30.26±11.28)cm3,差异无统计学意义(P0.05);入院72 h后患者脑水肿总体积为(49.37±14.23)cm3,较入院时脑水肿总体积[(30.26±11.28)cm3]显著增大(P0.05);相对水肿体积增加1.13倍。单因素方差分析显示,高血清铁蛋白水平(β=13.592,P0.01)及糖尿病(β=13.592,P0.01)是血肿周围水肿体积增大的独立危险因素。入院当天,患者血清铁蛋白水平和相对水肿大小之间无明显相关性(r=0.11,P0.05);入院72 h后相对水肿体积与血清铁蛋白呈显著正相关(r=0.67,P0.01)。结论血清铁蛋白是反映高血压脑出血后血肿周围脑水肿增大程度的一个重要指标,其在血肿周围继发性脑水肿的发生中起到重要的作用。
[Abstract]:Objective to investigate the relationship between serum ferritin and perihematomas cerebral edema after hypertensive intracerebral hemorrhage (hypertensive intracerebral hemorrhage), and to analyze the role and mechanism of ferritin in the occurrence of perihematomas cerebral edema. Methods the clinical data and laboratory data of 38 patients with hypertensive intracerebral hemorrhage treated in the Department of Neurosurgery, Fengtai Youanmen Hospital, Beijing from January 2014 to June 2015 were collected. All patients were examined by serum ferritin and skull CT at admission and 72 hours after admission. The volume of hematomas, the total volume of brain edema and the corrected relative edema volume were calculated at admission and 72 hours after admission. Single factor variance analysis was used to analyze the factors related to perihematomas cerebral edema after intracerebral hemorrhage, and Spearman correlation coefficient was used to analyze the correlation between serum ferritin and relative perihematomas volume. Results the volume of cerebral hematomas was (13.25 卤5.54) cm3, on the day of admission, and there was no significant difference in the volume of cerebral hematomas (30.26 卤11.28) cm3, after admission 72 hours after admission (P 0.05). After 72 hours of admission, the total volume of brain edema was (49.37 卤14.23) cm3, which was significantly higher than that of (30.26 卤11.28) cm3 at admission (P 0.05), and the relative volume of edema increased by 1.13 times. Single factor analysis of variance showed that high serum ferritin level (尾 = 13.592, P 0.01) and diabetes mellitus (尾 = 13.592, P 0.01) were independent risk factors for the increase of edema volume around hematomas. On the day of admission, there was no significant correlation between serum ferritin level and relative edema size (r 鈮，
本文编号：2480308
[Abstract]:Objective to investigate the relationship between serum ferritin and perihematomas cerebral edema after hypertensive intracerebral hemorrhage (hypertensive intracerebral hemorrhage), and to analyze the role and mechanism of ferritin in the occurrence of perihematomas cerebral edema. Methods the clinical data and laboratory data of 38 patients with hypertensive intracerebral hemorrhage treated in the Department of Neurosurgery, Fengtai Youanmen Hospital, Beijing from January 2014 to June 2015 were collected. All patients were examined by serum ferritin and skull CT at admission and 72 hours after admission. The volume of hematomas, the total volume of brain edema and the corrected relative edema volume were calculated at admission and 72 hours after admission. Single factor variance analysis was used to analyze the factors related to perihematomas cerebral edema after intracerebral hemorrhage, and Spearman correlation coefficient was used to analyze the correlation between serum ferritin and relative perihematomas volume. Results the volume of cerebral hematomas was (13.25 卤5.54) cm3, on the day of admission, and there was no significant difference in the volume of cerebral hematomas (30.26 卤11.28) cm3, after admission 72 hours after admission (P 0.05). After 72 hours of admission, the total volume of brain edema was (49.37 卤14.23) cm3, which was significantly higher than that of (30.26 卤11.28) cm3 at admission (P 0.05), and the relative volume of edema increased by 1.13 times. Single factor analysis of variance showed that high serum ferritin level (尾 = 13.592, P 0.01) and diabetes mellitus (尾 = 13.592, P 0.01) were independent risk factors for the increase of edema volume around hematomas. On the day of admission, there was no significant correlation between serum ferritin level and relative edema size (r 鈮，
本文编号：2480308
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