“鸡尾酒疗法”治疗帕金森病痴呆疗效观察

发布时间：2019-05-27 04:50

【摘要】：目的观察鸡尾酒疗法治疗帕金森病痴呆(PDD)的疗效和安全性。方法 60例PDD患者随机分为治疗组(30例)和对照组(30例)。对照组口服多奈哌齐10 mg、1次/d。治疗组在此基础上加用丁苯酞0.2 g口服,3次/d;奥拉西坦0.8 g口服,3次/d;银杏叶片2片口服,3次/d,疗程6个月。分别于治疗前和治疗3、6个月时,采用蒙特利尔认知评估量表(Mo CA)、Blessed-Roth痴呆量表、痴呆严重程度临床评定量表(WMS)评分评定,并监测不良反应。结果治疗组和对照组治疗前Mo CA评分、Blessed-Roth评分及WMS评分差异无统计学意义(均P0.05)。治疗组和对照组治疗6个月时Mo CA评分、WMS评分均显著高于治疗前及治疗3个月,Blessed-Roth评分显著低于于治疗前及治疗3个月(P0.05~0.01)。与对照组比较,治疗组治疗6个月时Mo CA评分、WMS评分显著升高,Blessed-Roth评分显著降低(P0.05~0.01)。治疗组(16.67%)和对照组(13.33%)治疗后肝功能异常率差异无统计学意义(P0.05)。结论鸡尾酒疗法治疗PDD疗效优于传统疗法,且安全性高。
[Abstract]:Objective to observe the efficacy and safety of cocktail therapy in the treatment of Parkinson's disease dementia (PDD). Methods 60 patients with PDD were randomly divided into treatment group (n = 30) and control group (n = 30). The control group was treated with donepezil 10 mg,1 / d. On this basis, the treatment group was treated with butylphthalide 0.2 g, 3 times / d, oxetam 0.8 g, 3 times / d, and ginkgo biloba leaves 2 tablets, 3 times / d, the course of treatment was 6 months. Before treatment and 3 months and 6 months after treatment, the Montreal Cognitive Assessment scale (Mo CA), Blessed-Roth dementia scale and (WMS) score were used to evaluate the severity of dementia, and the adverse reactions were monitored. Results there was no significant difference in Mo CA score, Blessed-Roth score and WMS score between the treatment group and the control group before treatment (P 0.05). The Mo CA score, WMS score and Blessed-Roth score of the treatment group and the control group at 6 months after treatment were significantly higher than those before treatment and 3 months after treatment, and the Blessed-Roth scores were significantly lower than those before treatment and 3 months after treatment (P 0.05 鈮，

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