偏头痛发作间期疼痛刺激的脑磁图研究

发布时间：2019-06-20 15:22

【摘要】：目的探讨偏头痛患者在发作间期大脑对疼痛电刺激的反应特点。方法收集30例发作间期的无先兆偏头痛患者(偏头痛组)和30名年龄、性别相匹配的健康对照者(对照组),利用脑磁图描记术记录正中神经疼痛电刺激下诱导的脑电磁信号。比较偏头痛组与对照组之间在痛觉处理上的差异。结果与对照组相比,偏头痛组疼痛电刺激疼痛阈值显著降低(P0.05),疼痛电刺激产生的体感诱发磁场M20潜伏期明显延长(P0.01)。偏头痛组疼痛诱发Gamma振荡平均能量较对照组显著增强(P0.01),且Gamma震荡能量值与视觉模拟评分法(VAS)、偏头痛残疾程度评估量表(MIDAS)评分均呈正相关(VAS左手:r=0.45,P0.05;VAS右手:r=0.46,P0.05;MIDAS左手:r=0.47,P0.01;MIDAS右手:r=0.59,P0.01)。结论偏头痛患者发作间期存在疼痛感觉异常,且痛觉刺激相关的皮质兴奋性增高。
[Abstract]:Objective to investigate the response of brain to pain electrical stimulation in migraine patients during interictal period. Methods 30 interictal migraine patients (migraine group) and 30 age and sex matched healthy controls (control group) were collected. The brain electromagnetic signals induced by median nerve pain were recorded by magnetography. The difference of pain management between the migraine group and the control group was compared. Results compared with the control group, the pain threshold of pain electrical stimulation in migraine group was significantly lower than that in control group (P 0.05), and the latency of somatosensory induced magnetic field M20 induced by pain electrical stimulation was significantly prolonged (P 0.01). The average energy of pain induced Gamma oscillations in migraine group was significantly higher than that in control group (P0.01), and there was a positive correlation between Gamma concussion energy and (MIDAS) score of (VAS), migraine disability assessment scale (VAS left hand: r 鈮，

本文编号：2503329