子瘤对脑动脉瘤破裂风险影响的血流动力学研究

发布时间：2019-06-26 15:09

【摘要】：为了阐明子瘤对于脑动脉瘤破裂风险的血流动力学影响机制,获取带子瘤和未带子瘤的患者CT图像信息进行三维重建,得到3D模型——带子瘤模型和未带子瘤模型2种,通过血流动力学计算方法,利用Fluent软件计算并得到计算结果.分析结果得到两模型各类血流动力学参数——内部流场、壁面切应力(WSS)、切应力震荡因子(OSI)、粒子滞留时间(RRT),并进行比较分析,得到带子瘤模型与未带子瘤模型的结果之间的差异,得出带子瘤模型对其发展机制的影响.结果表明:带子瘤的模型内部流场更不稳定,WSS更低(未带子瘤模型WSS最大值为9.5 Pa,而带子瘤模型WSS最大值为6 Pa);同时,带子瘤的模型高OSI的面积大于未带子瘤模型的高OSI面积;而带子瘤模型的高RRT面积也远大于未带子瘤模型的高RRT面积,说明带子瘤的瘤内部血流方向杂乱,更容易产生血栓.因此,带子瘤模型的OSI和RRT普遍偏高,而WSS偏低.针对带子瘤的模型,内部流场的差异性主要表现为:低WSS、高OSI和高RRT,而这三者对动脉瘤的生长发展有很大影响;同时说明WSS、OSI、RRT是判断动脉瘤破裂的有效指标,对研究脑动脉瘤的破裂机制具有一定的意义.
[Abstract]:In order to elucidate the hemodynamic mechanism of subtumor on the risk of cerebral aneurysm rupture, the CT image information of patients with and without subtumor was obtained for three-dimensional reconstruction, and two kinds of 3D models, bearing tumor model and non-subtumor model, were obtained. The hemodynamic calculation method was used to calculate the results by Fluent software. The results show that the hemodynamic parameters of the two models-internal flow field and wall shear stress (WSS), shear stress shock factor (OSI), particle retention time (RRT), are obtained and compared and analyzed. The difference between the results of the tumor model and the model without the tumor is obtained, and the influence of the tumor model on the development mechanism of the model is obtained. The results showed that the internal flow field of the model with subtumor was more unstable and the WSS was lower (the maximum WSS of the model without tumor was 9.5 Pa, and the maximum value of WSS of the model with tumor was 6 Pa);). At the same time, the area of high OSI in the model with tumor was larger than that in the model without tumor. The high RRT area of the subtumor model was much larger than that of the non-subtumor model, which indicated that the internal blood flow direction of the tumor with subtumor was disordered and thrombus was more likely to occur. Therefore, the OSI and RRT of the tumor model were generally higher than those of the WSS model. According to the model with tumor, the difference of internal flow field is as follows: low WSS, high OSI and high RRT, which have great influence on the growth and development of aneurysm, at the same time, it is shown that WSS,OSI,RRT is an effective index to judge the rupture of aneurysm, which is of great significance to the study of the mechanism of rupture of cerebral aneurysm.
【作者单位】：北京工业大学生命科学与生物工程学院;
【基金】：国家自然科学基金资助项目(91430215,11572014,11602007) 北京市教育委员会资助项目(KM201510005028) 北京市优秀人才资助项目(2014000020124G045) 北京工业大学“智能制造领域大科研推进计划”资助项目
【分类号】：R743

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