经颅多普勒超声辅助巴曲酶治疗对预防进展性缺血性脑卒中作用的多因素分析
发布时间：2019-07-01 10:50
【摘要】：目的探讨在静脉应用巴曲酶的同时应用经颅多普勒超声(TCD)连续监测责任血管,是否可通过其超声波的理化效应增强巴曲酶预防进展性缺血性脑卒中(PIS)的疗效。方法 100例连续纳入急性脑梗死患者随机分为对照组和观察组,每组50例。对照组患者接受急性脑梗死常规治疗及静脉巴曲酶治疗,观察组患者在此基础上在巴曲酶治疗时应用TCD连续监测责任血管。除去失访患者,最终对照组47例及观察组43例患者纳入统计。比较两组患者治疗前的基线特征、治疗后3 d的血纤维蛋白原值、治疗后1周的美国国立卫生研究院卒中量表(NIHSS)评分及PIS发生率;最后应用多因素分析探讨在静脉应用巴曲酶的同时使用TCD连续监测责任血管是否是预防PIS发生的独立影响因素。结果两组患者基线特征差异无统计学意义,观察组治疗后1周的血纤维蛋白原值、NIHSS评分、1周内PIS发生率均显著低于对照组(P=0.033、0.002、0.049);经二元logistic回归分析,在静脉应用巴曲酶的同时使用TCD连续监测责任血管是预防PIS发生的独立影响因素。结论对于急性脑梗死患者,在静脉应用巴曲酶治疗的同时使用TCD对责任脑血管连续监测1 h能够增强巴曲酶的降纤作用,有效减少PIS发生。
[Abstract]:Objective to investigate whether batroxobin can enhance the efficacy of batroxobin in the prevention of progressive ischemic stroke (PIS) by continuously monitoring the responsible vessels by transcranial Doppler ultrasound (TCD) in conjunction with the intravenous application of batroxobin. Methods 100 patients with acute cerebral infarction were randomly divided into control group (n = 50) and observation group (n = 50). The patients in the control group were treated with routine treatment of acute cerebral infarction and intravenous batroxobin. On this basis, the patients in the observation group were treated with TCD for continuous monitoring of responsible vessels. Except for the lost patients, 47 patients in the control group and 43 patients in the observation group were included in the statistics. The baseline characteristics before treatment, the blood fibrin value 3 days after treatment, the (NIHSS) score and the incidence of PIS in the National Institutes of Health Stroke scale 1 week after treatment were compared between the two groups. Finally, multivariate analysis was used to explore whether the continuous monitoring of responsible vessels with batroxobin and TCD was an independent factor to prevent the occurrence of PIS. Results there was no significant difference in the baseline characteristics between the two groups. The blood fibrin value, NIHSS score and the incidence of PIS within 1 week in the observation group were significantly lower than those in the control group (P 鈮，
本文编号：2508414
[Abstract]:Objective to investigate whether batroxobin can enhance the efficacy of batroxobin in the prevention of progressive ischemic stroke (PIS) by continuously monitoring the responsible vessels by transcranial Doppler ultrasound (TCD) in conjunction with the intravenous application of batroxobin. Methods 100 patients with acute cerebral infarction were randomly divided into control group (n = 50) and observation group (n = 50). The patients in the control group were treated with routine treatment of acute cerebral infarction and intravenous batroxobin. On this basis, the patients in the observation group were treated with TCD for continuous monitoring of responsible vessels. Except for the lost patients, 47 patients in the control group and 43 patients in the observation group were included in the statistics. The baseline characteristics before treatment, the blood fibrin value 3 days after treatment, the (NIHSS) score and the incidence of PIS in the National Institutes of Health Stroke scale 1 week after treatment were compared between the two groups. Finally, multivariate analysis was used to explore whether the continuous monitoring of responsible vessels with batroxobin and TCD was an independent factor to prevent the occurrence of PIS. Results there was no significant difference in the baseline characteristics between the two groups. The blood fibrin value, NIHSS score and the incidence of PIS within 1 week in the observation group were significantly lower than those in the control group (P 鈮，
本文编号：2508414
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