LAA型脑梗死与半乳糖凝集素-3水平的相关性的分析
发布时间：2019-07-01 17:20
【摘要】：目的探讨血浆半乳糖凝集素水平与LAA型脑梗死患者血管病变程度及患者的预后的关系。方法按照TOAST分型,选取98例大动脉粥样硬化型(Large artery atherosclerotic,LAA)脑梗死患者。入院后详细询问病史,记录患者的性别、年龄、吸烟、饮酒史及既往病史(糖尿病、冠心病史)。行颅脑CT、MRA、TCD,颈部血管超声、颈部血管CTA、及心脏超声检查,排除其它病变,确诊为LAA型脑梗死;并将患者按血管的病变支数分组:单支血管病变、双支血管病变及多支血管病变组。应用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)测定所有研究对象血浆半乳糖凝集素-3水平,比较3组患者的血浆半乳糖凝集素-3水平;同时,对患者进行3个月的随访,给予m RS评分,分为m RS≥3分和m RS3分两组,结合受试者工作特征曲线(receiver operating characteristic curve,ROC)评估血浆半乳糖凝集素-3与患者预后的关系。结果各组患者的半乳糖凝集素-3水平比较:多支病变组显著高于双支和单支病变组(t=-4.536、-7.298,P=0.000、0.000),双支病变组显著高于单支病变组(t=-2.542,P=0.014)。患者的性别、年龄、高血压病、冠心病、糖尿病、吸烟的影响因素在组间差异无统计学意义。血糖水平、低密度脂蛋白水平及总胆固醇及半乳糖凝集素-3水平的组间差异有统计学意义(P0.05)。患者m RS评分方面,独立样本t检验表明分组间差异具有统计学意义(t=-5.851,P0.000)。Spearman等级相关证实血浆半乳糖凝集素-3水平与m RS评分成正相关(r=0.519,P=0.000)。患者血浆gal-3水平与患者预后的ROC曲线下面积为0.805(95%CI=0.717-0.892,P=0.000)。结论在LAA型脑梗死患者,血浆半乳糖凝集素-3水平与血管病变支数呈正相关;往往患者的血管病变支数越多,患者的动脉粥样硬化程度就越广泛。同时患者的血浆半乳糖凝集素-3水平还与患者的m RS评分呈正相关,血浆半乳糖凝集素-3水平越高,患者的m RS评分也越高,预后越差。提示半乳糖凝集素-3可能参与了缺血性脑卒中患者脑动脉粥样硬化的炎性发病机制,参与了疾病的进展过程。本研究提示患者的半乳糖凝集素-3水平有希望成为评价LAA型脑梗死患者的动脉粥样硬化病变广泛程度及预后的血浆标志物。
[Abstract]:Objective to investigate the relationship between plasma galactose lectin level and the degree of vascular lesions and prognosis in patients with LAA cerebral infarction. Methods according to TOAST classification, 98 patients with cerebral infarction with atherosclerotic (Large artery atherosclerotic,LAA were selected. Enquire about the medical history after admission and record the patient's sex, age, smoking, drinking history and past history (diabetes, coronary heart disease). Brain CT,MRA,TCD, cervical vascular ultrasound, cervical vascular CTA, and cardiac ultrasound were performed to exclude other lesions and diagnose LAA cerebral infarction, and the patients were divided into three groups according to the number of vessel lesions: single vessel disease, double vessel disease and multi-vessel disease group. Plasma galactose lectin-3 levels were measured by enzyme-linked immunosorbent assay (enzyme-linked immunosorbent assay,ELISA), and plasma galactose lectin-3 levels were compared among the three groups. At the same time, the patients were followed up for 3 months, and the patients were divided into two groups: m RS 鈮，
本文编号：2508662
[Abstract]:Objective to investigate the relationship between plasma galactose lectin level and the degree of vascular lesions and prognosis in patients with LAA cerebral infarction. Methods according to TOAST classification, 98 patients with cerebral infarction with atherosclerotic (Large artery atherosclerotic,LAA were selected. Enquire about the medical history after admission and record the patient's sex, age, smoking, drinking history and past history (diabetes, coronary heart disease). Brain CT,MRA,TCD, cervical vascular ultrasound, cervical vascular CTA, and cardiac ultrasound were performed to exclude other lesions and diagnose LAA cerebral infarction, and the patients were divided into three groups according to the number of vessel lesions: single vessel disease, double vessel disease and multi-vessel disease group. Plasma galactose lectin-3 levels were measured by enzyme-linked immunosorbent assay (enzyme-linked immunosorbent assay,ELISA), and plasma galactose lectin-3 levels were compared among the three groups. At the same time, the patients were followed up for 3 months, and the patients were divided into two groups: m RS 鈮，
本文编号：2508662
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