唑尼沙胺添加治疗难治性部分性癫痫发作疗效和安全性的meta分析

发布时间：2019-07-02 13:07

【摘要】：目的：系统评价唑尼沙胺添加治疗难治性部分性癫痫发作疗效和药物的安全性,为临床治疗难治性部分性发作提供证据。 方法：计算机检索2000年1月-2013年12月MEDLINE、EBbase、Pubmed、 FMJS、社会科学引文索引、维普中文科技期刊、中国知网相关期刊论文和中国生物医学文献数据库,并手工检索相关杂志,由两名研究者独立进行质量评价及数据分析,用RevMan5.2统计软件进行Meta分析。 结果：检索到8篇唑尼沙胺的双盲、随机、安慰剂对照的临床试验,共1433例受试者(唑尼沙胺组751例,安慰剂对照组682例)。Meta分析结果显示：唑尼沙胺组癫痫部分性发作频率减少≥50%的病例数高于对照组,差异有统计学意义[OR=2.26,95%CI (1.79,2.85), P0.00001];唑尼沙胺组失访率与安慰剂对照组之间差异无统计学意义[OR=1.16,95%CI (0.82,1.63), P=0.39];治疗期间常见药物不良反应包括疲乏、头晕、嗜睡、厌食等,各种不良反应实验组和对照组之间差异均无统计学意义[OR=1.38,95%CI(0.66,2.89),P=0.40; OR=1.33,95%CI (0.79,2.25), P=0.28; OR=1.29,95%CI (0.73,2.27), P=0.38; OR=2.09,95%CI (0.81,5.37), P=0.13]. 结论：唑尼沙胺添加治疗难治性部分性癫痫发作的疗效与安慰剂组相比效果显著,耐受性好。
[Abstract]:Objective: to systematically evaluate the efficacy and safety of zonisalamine in the treatment of refractory partial seizures, and to provide evidence for clinical treatment of refractory partial seizures. Methods: from January 2000 to December 2013, MEDLINE,EBbase,Pubmed, FMJS, social science citation index, Weipu Chinese sci-tech journal, Chinese journal full-text database and Chinese biomedical literature database were searched by computer, and related magazines were searched by hand. The quality evaluation and data analysis were carried out independently by two researchers, and Meta analysis was carried out with RevMan5.2 statistical software. Results: eight double-blind, randomized, placebo-controlled clinical trials of zonisalamine were searched, with a total of 1433 subjects (751 in zonisalamine group and 682 in placebo control group). Meta-analysis showed that the number of cases with partial seizures decreased by more than 50% in zonisalamine group was significantly higher than that in control group [OR=2.26,95%CI (1.79, 2.85), P0.00001]. There was no significant difference in the loss of visit rate between the zonisalamine group and the placebo control group [OR=1.16,95%CI (0.82, 1.63), P 鈮，

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