丹参多酚酸盐联合灯盏生脉胶囊对缺血性脑卒中神经功能缺损程度及血液流变学的影响

发布时间：2019-08-16 13:58

【摘要】：目的探讨丹参多酚酸盐联合灯盏生脉胶囊对缺血性脑卒中患者神经功能缺损程度及血液流变学的影响,以及临床疗效的评价。方法选取72例缺血性脑卒中患者,依据建档顺序分为灯盏生脉组和对照组,各36例。对照组采用常规治疗加丹参多酚酸盐的治疗方案,灯盏生脉组在对照组质量方案上加用灯盏生脉胶囊,两组均持续治疗14 d。统计对比两组临床疗效、不良反应发生率及治疗前后神经功能缺损评分(NIHSS)、日常生活能力评分(BI)、血液流变学指标(纤维蛋白原、红细胞压积、血浆黏度、全血高切黏度、全血低切黏度)水平变化情况。结果两组治疗前NIHSS评分及BI评分比较,差异无统计学意义(P0.05),治疗后灯盏生脉组NIHSS评分低于对照组,BI评分高于对照组,差异有统计学意义(P0.05);灯盏生脉组治疗有效率91.67%(33/36)高于对照组72.22%(26/36),差异有统计学意义(P0.05);两组治疗前纤维蛋白原、红细胞压积、血浆黏度、全血高切黏度、全血低切黏度水平比较,差异无统计学意义(P0.05),治疗后灯盏生脉组各指标水平低于对照组,差异有统计学意义(P0.05);灯盏生脉组不良反应发生率8.33%(3/36)与对照组13.87%(5/36)比较,差异无统计学意义(P0.05)。结论联合采用丹参多酚酸盐及灯盏生脉胶囊治疗缺血性脑卒中效果显著,可有效改善患者神经功能及日常生活能力、血液流变学,提高治疗效果,且安全性较高。
[Abstract]:Objective to investigate the effect of Salvia miltiorrhiza polyphenols combined with Erigeron Shengmai capsule on the degree of neurological deficit and hemorheology in patients with ischemic stroke, and to evaluate the clinical effect. Methods 72 patients with ischemic stroke were divided into Erigeron breviscapus Shengmai group (n = 36) and control group (n = 36). The control group was treated with routine treatment plus salvia miltiorrhiza polyphenols, and the group with Erigeron breviscapus Shengmai capsule was added to the quality scheme of the control group for 14 days. The clinical efficacy, the incidence of adverse reactions and the changes of (BI), hemorheological indexes (fibrinogen, hematocrit, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity) were compared between the two groups before and after treatment. Results there was no significant difference in NIHSS score and BI score between the two groups before treatment (P 0.05). After treatment, the NIHSS score of Erigeron breviscapus Shengmai group was lower than that of the control group, and the BI score was significantly higher than that of the control group (P 0.05). The effective rate of Erigeron breviscapus Shengmai group was 41.67% (33 鈮，

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