血脑脊液屏障上P-糖蛋白的研究进展
发布时间：2019-08-24 12:36
【摘要】：血脑脊液屏障是由脑微血管内皮细胞、星形胶质细胞和周皮细胞等组成的动态生理结构,对中枢神经系统内环境稳态的维持发挥至关重要的作用。P-糖蛋白作为血脑脊液屏障上一种常见膜蛋白,它在脑微血管内皮细胞中大量表达,限制毒性物质和大量治疗中枢神经系统的药物进入脑内。因此对P-糖蛋白在血脑脊液屏障中的外排转运机制的了解是神经系统疾病治疗的一个突破点。该文主要对P-糖蛋白的基本结构、转运途径、在生理与病理情况下P-糖蛋白的调节机制以及P-糖蛋白抑制剂研究进展等进行综述,对中枢神经系统药物研发以及提高血脑脊液屏障对治疗药物通透性研究提供参考。
[Abstract]:The blood-cerebrospinal fluid barrier is a dynamic physiological structure composed of cerebral microvascular endothelial cells, astrocytes and peri-endothelial cells, which plays an important role in the maintenance of environmental homeostasis in the central nervous system. P-glycoprotein, as a common membrane protein on the blood-cerebrospinal fluid barrier, is heavily expressed in cerebral microvascular endothelial cells, restricting toxic substances and a large number of drugs for the treatment of the central nervous system into the brain. Therefore, the understanding of the efflux and transport mechanism of P-glycoprotein in the blood-cerebrospinal fluid barrier is a breakthrough point in the treatment of nervous system diseases. In this paper, the basic structure and transport pathway of P-glycoprotein, the regulation mechanism of P-glycoprotein under physiological and pathological conditions and the research progress of P-glycoprotein inhibitor were reviewed, which provided a reference for the research and development of drugs in central nervous system and the improvement of blood-cerebrospinal fluid barrier in the treatment of drug permeability.
【作者单位】： 河北北方学院药学系;
【基金】：国家自然科学基金项目(No.81274005) 河北省自然科学基金项目(No.2016208058)
【分类号】：R741
本文编号：2528969
[Abstract]:The blood-cerebrospinal fluid barrier is a dynamic physiological structure composed of cerebral microvascular endothelial cells, astrocytes and peri-endothelial cells, which plays an important role in the maintenance of environmental homeostasis in the central nervous system. P-glycoprotein, as a common membrane protein on the blood-cerebrospinal fluid barrier, is heavily expressed in cerebral microvascular endothelial cells, restricting toxic substances and a large number of drugs for the treatment of the central nervous system into the brain. Therefore, the understanding of the efflux and transport mechanism of P-glycoprotein in the blood-cerebrospinal fluid barrier is a breakthrough point in the treatment of nervous system diseases. In this paper, the basic structure and transport pathway of P-glycoprotein, the regulation mechanism of P-glycoprotein under physiological and pathological conditions and the research progress of P-glycoprotein inhibitor were reviewed, which provided a reference for the research and development of drugs in central nervous system and the improvement of blood-cerebrospinal fluid barrier in the treatment of drug permeability.
【作者单位】： 河北北方学院药学系;
【基金】：国家自然科学基金项目(No.81274005) 河北省自然科学基金项目(No.2016208058)
【分类号】：R741
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