A protease-activated receptor 1 antagonist protects against

发布时间：2021-02-04 13:52

　　Cerebral ischemia/reperfusion injury is partially mediated by thrombin, which causes brain damage through protease-activated receptor 1（PAR1）. However, the role and mechanisms underlying the effects of PAR1 activation require further elucidation. Therefore, the present study investigated the effects of the PAR1 antagonist SCH79797 in a rabbit model of global cerebral ischemia induced by cardiac arrest. SCH79797 was intravenously administered 10 minutes after the model was established. Forty-eigh... 

【文章来源】：Neural Regeneration Research. 2017,12(02)

【文章页数】：8 页

【文章目录】：
Graphical Abstract
Introduction
Materials and Methods
    Animal preparation
    Establishment of transient global cerebral I/R injury model and drug administration
    Enzyme linked immunosorbent assay（ELISA）
    Cerebral performance category score
    Western blot assay
    Histological evaluation
    Statistical analysis
Results
    Physiological,hemodynamic and arterial blood gas changes of global cerebral I/R injury after cardiopulmonary resuscitation
    SCH79797 alleviated neurological dysfunction after transient global cerebral I/R injury
    SCH79797 reduced apoptosis in the hippocampus after transient global cerebral I/R injury
    SCH79797 increased ERK phosphorylation and decreased c-Jun levels after transient global cerebral I/R injury
    SCH79797 effects on neutrophil infiltration after transient global cerebral I/R injury
Discussion


【参考文献】：
期刊论文
[1]Lateral intracerebroventricular injection of Apelin-13 inhibits apoptosis after cerebral ischemia/reperfusion injury[J]. Xiao-ge Yan,Bao-hua Cheng,Xin Wang,Liang-cai Ding,Hai-qing Liu,Jing Chen,Bo Bai.  Neural Regeneration Research. 2015(05)
[2]Ligustrazine monomer against cerebral ischemia/reperfusion injury[J]. Hai-jun Gao,Peng-fei Liu,Pei-wen Li,Zhuo-yan Huang,Feng-bo Yu,Ting Lei,Yong Chen,Ye Cheng,Qing-chun Mu,Hai-yan Huang.  Neural Regeneration Research. 2015(05)



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